Cellular distribution and control of intracellular pH signalling in cerebellar Purkinje neurones

医生们目前用一套叫做碳酸酐酶抑制剂的药物来治疗癫痫、运动障碍和某些形式的偏头痛患者。这些药物在临床上起作用的原因尚不清楚。我们的基础科学指出了大脑神经细胞计算部分的pH值变化。我们目前的证据不仅解释了为什么这些药物有效，而且还表明神经细胞功能的一个主要部分被神经科学界所忽视。我们的工作旨在更好地了解神经元pH值变化在正常神经功能中的作用。然后，我们可以将这些变化与碳酸酐酶敏感性疾病患者或类似疾病的动物模型中观察到的变化进行比较。

Doctors currently treat patients with epilepsy, movement disorders and some forms of migraine with a set of drugs called carbonic anhydrase inhibitors. The reason why these drugs work, clinically, is unknown. Our basic science points to an action on pH changes in the computational part of nerve cells in the brain. Our current evidence not only provides an explanation as to why these drugs work, but also suggests that a major part of nerve cell function is being ignored by the neuroscience community. Our work is aimed at understanding better the role of neuronal pH changes in normal nerve function. We can then compare these changes with those seen in either patients with carbonic anhydrase sensitive disorders or in animal models of similar diseases.