Cellular distribution and control of intracellular pH signalling in cerebellar Purkinje neurones

小脑浦肯野神经元细胞内 pH 信号的细胞分布和控制

• 批准号: G0400614/1
• 负责人: Christof Schwiening
• 金额: $ 37.83万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0400614%2F1
• 关键词: Cellular; distribution; control; intracellular; pH

Doctors currently treat patients with epilepsy, movement disorders and some forms of migraine with a set of drugs called carbonic anhydrase inhibitors. The reason why these drugs work, clinically, is unknown. Our basic science points to an action on pH changes in the computational part of nerve cells in the brain. Our current evidence not only provides an explanation as to why these drugs work, but also suggests that a major part of nerve cell function is being ignored by the neuroscience community. Our work is aimed at understanding better the role of neuronal pH changes in normal nerve function. We can then compare these changes with those seen in either patients with carbonic anhydrase sensitive disorders or in animal models of similar diseases.

目前，医生们用一种叫做碳酸酐酶抑制剂的药物来治疗癫痫、运动障碍和某些形式的偏头痛患者。这些药物在临床上起作用的原因尚不清楚。我们的基础科学指出，大脑中神经细胞的计算部分对pH值变化的作用。我们目前的证据不仅解释了为什么这些药物起作用，而且还表明神经细胞功能的一个主要部分被神经科学界所忽视。我们的工作旨在更好地理解神经元pH值变化在正常神经功能中的作用。然后，我们可以将这些变化与碳酸酐酶敏感疾病患者或类似疾病的动物模型中所见的变化进行比较。