Identification of novel PTH anabolic targets in osteoblasts

成骨细胞中新型 PTH 合成代谢靶标的鉴定

• 批准号: nhmrc : 1034839
• 负责人: Prof Matthew Gillespie
• 金额: $ 36.49万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-novel-pth-targets-osteoblasts/110938
• 关键词: Identification; novel; PTH; anabolic; targets

Osteoporosis is a major disease affecting Australians. Whilst there are a number of drugs available that will reduce bone loss, there are few drugs available that build new bone, and little is known of the action of these drugs. New targets have been identified that modulate bone formation, and this project aims to validate these in appropriate models and determine their mechanism of action.

骨质疏松症是影响澳大利亚人的主要疾病。虽然有许多药物可以减少骨质流失，但很少有药物可以构建新骨，而且人们对这些药物的作用知之甚少。已经确定了调节骨形成的新目标，该项目旨在在适当的模型中验证这些目标并确定其作用机制。