Diabetes Prevention in People from Bangladesh; A Pilot Trial in East London

成年人患糖尿病的人数正在增加，在欧洲，未来10年将增加至少50%。该问题在南亚裔人群中尤其严重，在南亚裔人群中，T2 D的患病率是白色欧洲人的3-6倍，并且该疾病的发病时间比欧洲人早10-15年。南亚人T2 D的终生风险约为三分之一，在印度城市，最近的调查表明，T2 D和糖耐量受损（IGT）在20岁以上的所有成年人中占四分之一。此外，在欧洲和北美，20岁以下的人群中，T2 D的增加令人担忧，这与肥胖症的患病率增加有关。这种慢性疾病导致心脏病发作、中风、视力丧失和肾衰竭的增加，在英国约占NHS医疗支出的十分之一。从美国，芬兰和印度的研究中，我们知道通过运动和饮食改变以及使用药物（二甲双胍）来预防糖尿病是可能的。我们提出了一项研究，以确定正确的方法来测试这种类型的计划是否会成功地预防糖尿病的人在高风险的疾病在少数民族群体，孟加拉国社区在东伦敦。

The number of people developing diabetes as adults is growing and in Europe set to increase by at least 50% in the next 10 years. The problem is particularly intense in people of south Asian origin, where there is 3-6 times prevalence of T2D and the disease presents 10-15 years earlier compared to white Europeans. The lifetime risk for T2D in South Asians is around one in three, and in urban India recent surveys would suggest that T2D and impaired glucose tolerance (IGT) are present in 1 in 4 of all adults over the age of 20 years. Furthermore, in people under the age of 20 years of age there is an alarming increase in T2D associated with increasing prevalence of obesity in Europe and North America. This chronic disease results in increased heart attacks, strokes, loss of vision and kidney failure and in the UK accounts for approximately one tenth of the NHS health expenditure. From research in the US, Finland and India, we know it is possible to prevent diabetes with a programme of exercise and changes in diet, as well as use of a drug (metformin). We propose a research study to determine the right methods to test whether this type of programme will be successful in preventing diabetes in people at high risk of the disease in an ethnic minority group, the Bangladeshi community in east London.