Alpha7 nicotonic receptor actions on GABAergic synapses

Alpha7烟碱受体对GABA能突触的作用

• 批准号: G0501424/1
• 负责人: Dimitri Kullmann
• 金额: $ 54.93万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0501424%2F1
• 关键词: Alpha7; nicotonic; receptor; actions; GABAergic

Nicotine derived from tobacco acts on receptors in the brain, which are normally activated by the endogenous neurotransmitter acetylcholine. Although nicotine abuse is an important cause of premature death and disease, activation of nicotinic receptors enhances cognitive performance. How it does so is not known. We have recently discovered a powerful effect of activation of a subtype of nicotinic receptors on inhibitory transmission in a subset of neurons in the brain. We propose to explore the underlying mechanisms, and to investigate the consequences of this phenomenon for network function.

源自烟草的尼古丁作用于大脑中的受体，这些受体通常由内源性神经递质乙酰胆碱激活。尽管尼古丁滥用是过早死亡和疾病的重要原因，但烟碱受体的激活可以增强认知能力。它是如何做到这一点的尚不清楚。我们最近发现烟碱受体亚型的激活对大脑中一部分神经元的抑制传递具有强大的作用。我们建议探索潜在机制，并研究这种现象对网络功能的影响。