The universal lentiviral packaging cell

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Inherited diseases are caused by mistakes in the DNA of patients. In the case of rare inherited immunodeficiencies diseases (Baby in the Bubble syndrome), they can be cured by delivering a correct copy of the faulty DNA using an engineered virus (gene therapy). This project is to be carried out by scientists in the MRC/UCL Medical Molecular Virology Centre at UCL. They will develop a safer and more efficient method to produce engineered viruses for clinical gene therapy trials.