High-Resolution Structure/Function Analysis of the Strand-Loop Network of RNA Polymerase

RNA 聚合酶链环网络的高分辨率结构/功能分析

• 批准号: G0501703/1
• 负责人: Robert Weinzierl
• 金额: $ 47.94万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0501703%2F1
• 关键词: Resolution; Structure; Function; Analysis; Strand

The majority of cells contain the same genetic material that encodes the structure of various cellular components. Differences in cell types (e.g. neurons as compared to muscle cells) arise because different parts of the genetic material are selectively read out. RNA polymerases (RNAPs) are a crucial part of the molecular machinery involved in this selective reading mechanism. To understand normal and pathological cellular conditions better we need to gain an improved insight of the molecular mechanisms underlying RNAP function. Such knowledge will result in more specifically targeted therapeutic applications, new diagnostic tools and help with the development of novel types of antibiotica

大多数细胞含有相同的遗传物质，编码各种细胞成分的结构。细胞类型的差异（例如，神经元与肌肉细胞相比）的出现是因为遗传物质的不同部分被选择性地读出。 RNA 聚合酶 (RNAP) 是参与这种选择性阅读机制的分子机制的重要组成部分。为了更好地了解正常和病理细胞状况，我们需要更好地了解 RNAP 功能的分子机制。这些知识将带来更有针对性的治疗应用、新的诊断工具，并有助于开发新型抗生素