Molecular organisation of the secretory and endocytic pathways

分泌和内吞途径的分子组织

• 批准号: G0501725/1
• 负责人: Martin Lowe
• 金额: $ 19.34万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0501725%2F1
• 关键词: Molecular; organisation; secretory; endocytic; pathways

All animal cells release proteins into and take up proteins from the surrounding fluid. They also transport proteins between internal compartments, each of which has a unique composition and a specific function. Transport out of and into cells, and between internal compartments, is crucial for the normal functioning of cells, as well as the inter-cellular communication that is essential in all animals. Defects in these transport steps are associated with many diseases. It is therefore important we understand how this transport operates at the molecular level. The aim of the work in this application is to apply the technique of high-resolution electron microscopy, combined with a variety of modern molecular approaches, to increase our understanding of a number of key transport steps. This will allow us to gain insights into how the transport pathways function in a healthy cell, and consequently how defects in particular aspects of this transport may contribute to disease.

所有的动物细胞都向周围的液体释放蛋白质，并从周围的液体中吸收蛋白质。它们还在内部隔室之间运输蛋白质，每个隔室都具有独特的组成和特定的功能。进出细胞以及内部隔室之间的运输对于细胞的正常功能以及所有动物中必不可少的细胞间通讯至关重要。这些运输步骤的缺陷与许多疾病有关。因此，重要的是我们了解这种运输如何在分子水平上运作。这项工作的目的是应用高分辨率电子显微镜技术，结合各种现代分子方法，以增加我们对一些关键运输步骤的理解。这将使我们能够深入了解运输途径如何在健康细胞中发挥作用，以及这种运输的特定方面的缺陷如何导致疾病。