Malaria Adenoviral Vaccine

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Malaria is one of the greatest causes of infectious mortality globally but no vaccine is available. For over ten years it has been known that a particular type of immune response can impart strong protection against malaria. This entails a cellular immune response by killer T cells against the malaria parasite growing in liver cells. A new type of attenuated safe virus that can carry malaria genes has been developed as a vaccine that can induce these killer cells very strongly and protect against rodent malaria. We shall generate a vaccine of this type and test its ability to protect vaccinated individuals against malaria infection. If successful this approach could help develop vaccines of a similar type against a variety of other diseases.