Pancreas Cancer Biospecimens Repository

胰腺癌生物样本库

• 批准号: 7886729
• 负责人: DANIEL D VON HOFF
• 金额: $ 59.49万
• 依托单位: TRANSLATIONAL GENOMICS RESEARCH INST
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7886729
• 关键词: Arizona; Aspirate substance; Blood; Blood specimen; Cancer Center; Cancerous; Clinical; Clinical Data; Collaborations; Collection; Communities; Computational Biology; Confidentiality; Data; Databases; Development; Drug or chemical Tissue Distribution; Ensure; Environmental Risk Factor; Equipment and supply inventories; Family history of; Freezing; Goals; Grant; Guidelines; Human; Informed Consent; Institutes; Institution; Internet; Liquid substance; Lymphocyte Harvest; Malignant neoplasm of pancreas; Medial; Medical; Medical center; Monitor; Nitrogen; Operative Surgical Procedures; Pancreas; Pancreatic Diseases; Participant; Pathologic; Patients; Pattern; Peripheral Blood Mononuclear Cell; Play; Progress Reports; Quality Control; Reagent; Reproduction spores; Research; Research Personnel; Role; Sampling; Serum; Services; Specimen; Therapeutic; Time; Tissue Banks; Tissues; Translational Research; Universities; Work; blood product; demographics; design; experience; isopentane; lymph nodes; neoplastic; pancreatic neoplasm; repository; research study; translational study; tumor

The Pancreas Cancer Biospecimens Repository (Core A) will provide investigators of this P01 with access to normal and neoplastic human pancreatic tissue, regional lymph nodes, tumor aspirates and blood from patients suffering from pre-cancerous and cancerous pancreatic diseases. Functions of the Core will include collection of tissues, clinical annotations, proper storage and distribution of tissue to investigators. The Core will play an essential role in ensuring adequate numbers of pancreatic specimens for translational research studies. Currently, under the GI SPORE Grant of the AZCC, pancreatic tumor specimens and blood products are to be collected within the Tucson medical community. The intent of Core A is not to duplicate the collection of these reagents, but rather to extend the number and diversity of available specimen types. Knowing the limitations of any single institute to collect ample numbers of specimens for research in pancreatic cancer, the Core has enlisted the collaboration of eight separate medical centers dealing with pancreatic diseases. These institutions will provide additional fresh specimens (cancerous and non-cancerous tissue, portions of regional lymph nodes, and blood products) that will be collected under Core A, creating a centralized repository of diverse pancreatic tissues and biospecimens for investigational studies. Human pancreatic tissue specimens (pancreatic cancer, normal pancreas, and pre-cancerous tissue) will be collected after immediate snap freezing in isopentane-cooled liquid nitrogen and also preserved in RNAlater". Portions of the regional lymph nodes collected at the time of surgical pancreatic exploration will be snap frozen or submitted in medial to allow harvesting of lymphocytes. Additionally, blood samples will be collected from each patient and separated into peripheral blood mononuclear cells and serum, which may be used for analysis. In collaboration with the GI SPORE investigators, specimens will be annotated in a shared database with regard to patient demographics, environmental risk, exposure, medical and family history and pathologic data. This comprehensive database will be developed in concert with the Pattern Analysis and Computational Biology Core (Core B). Additional blood samples and clinical progress reports will be obtained at 6 monthly intervals for two years. With appropriate confidentiality monitoring, information will be accessible via the Internet to the P01 researchers at the AZCC and participating institutions. Informed consent will be obtained for all participants according to NCI guidelines and with the approval of each institution's IRB.Distribution of specimens to investigators will be overseen and prioritized by the Pancreatic Bioresource Utilization Committee, which will be organized under this Core service.

胰腺癌生物样本库（核心 A）将为 P01 的研究人员提供访问 正常和肿瘤性人类胰腺组织、区域淋巴结、肿瘤抽吸物和患者血液 患有癌前期和癌性胰腺疾病。核心的功能将包括收集 组织、临床注释、组织的正确储存和向研究人员的分发。核心将扮演一个 在确保转化研究中有足够数量的胰腺标本方面发挥着重要作用。现在， 根据 AZCC 的 GI SPORE 资助，将收集胰腺肿瘤标本和血液制品 在图森医学界。核心 A 的目的不是重复收集这些试剂， 而是扩大可用标本类型的数量和多样性。了解任何单一产品的局限性 为了收集大量样本用于胰腺癌研究，核心已招募了 八个处理胰腺疾病的独立医疗中心合作。这些机构将提供 额外的新鲜样本（癌组织和非癌组织、部分区域淋巴结和血液） 产品）将在核心 A 下收集，创建一个不同胰腺组织的集中存储库 用于研究研究的生物样本。人类胰腺组织标本（胰腺癌、正常 立即在异戊烷冷却的液体中速冻后收集 氮气，也保存在 RNAlater 中”。手术时收集的部分区域淋巴结 胰腺探查将被快速冷冻或置于内侧以收集淋巴细胞。 此外，将从每位患者身上采集血液样本并分离成外周血单核细胞 细胞和血清，可用于分析。与 GI SPORE 研究人员合作，采集标本 将在共享数据库中对患者人口统计数据、环境风险、暴露情况进行注释， 医学和家族史以及病理数据。该综合数据库将与 模式分析和计算生物学核心（核心 B）。额外的血液样本和临床进展 两年内将每隔 6 个月获得一次报告。通过适当的保密监控， AZCC 和参与机构的 P01 研究人员可以通过互联网获取信息。 根据 NCI 指南，并经每个参与者的批准，将获得所有参与者的知情同意 机构的 IRB。向研究人员分发样本将由胰腺部门监督并确定优先顺序 生物资源利用委员会，该委员会将在该核心服务下组织。