Four-Dimensional Heterogeneity of Fluid Phase Biopsies in Cancer (4DB-Center)

描述（由申请人提供）：4DB中心将由PI Peter Kuhn（物理学）指导，并由高级合作研究者Kelly Bethel（肿瘤学）协助。两人都是中心咨询委员会（CAC）的投票成员，约翰·格里芬（血液学）和保罗·牛顿（数学/物理学）也将加入。沿着作为无表决权成员的四名外部科学顾问和一名NCI代表，他们将监督中心的所有方案和组织方面、与PS-OC网络的整合及其教育和外联使命。一个内部物理肿瘤学接口委员会将提供额外的指导和机构支持。CAC的一个主要职责是开发试点和跨网络项目，以进一步实现4DB中心的研究目标，并补充其他PS-OC网络中心的研究。项目经理Enrique Abola将负责中心的日常运营，并向Kuhn博士和Bethel博士报告，Kuhn博士和Bethel博士负责与PS-OC指导委员会（PSC）的沟通和互动。4DB中心的数据共享和通信将通过企业级软件系统进行整合，该系统包括数据库系统、门户网站和用于数据/样本跟踪和数据注释/协作的独立软件程序。

DESCRIPTION (provided by applicant): The 4DB Center will be directed by the PI, Peter Kuhn (physics), who will be assisted by senior co-investigator Kelly Bethel (oncology). Both are voting members of the Center Advisory Committee (CAC) and will be joined by John Griffin (hematology) and Paul Newton (mathematics/physics). Along with four external scientific advisors as non-voting members and an NCI representative, they will oversee all programmatic and organizational aspects of the Center, its integration with the PS-OC Network and its education and outreach mission. An internal physics oncology interface board will provide additional guidance and institutional support. A key aspect of the CAC's responsibilities will be the development of pilot and trans-network projects to further the 4DB Center research goals as well as to complement the research of the other PS-OC Network centers. The project manager, Enrique Abola, will be responsible for the day-to-day center operations and will report to Drs. Kuhn and Bethel, who are responsible for communication and interaction with the PS-OCs Steering Committee (PSC). The 4DB Center data sharing and communication will be integrated through an enterprise-class software system consisting of a database system, web portal and standalone software programs for data/sample tracking and data annotation/collaboration.