Four-Dimensional Heterogeneity of Fluid Phase Biopsies in Cancer (4DB-Center)

描述（由申请人提供）：4DB中心将由PI Peter Kuhn（物理学）领导，他将由高级联合研究员Kelly Bethel（肿瘤学）协助。两人都是中心咨询委员会（CAC）的投票成员，John Griffin（血液学）和Paul Newton（数学/物理）也将加入。他们将与四名作为无投票权成员的外部科学顾问和一名NCI代表一起，监督该中心的所有计划和组织方面、与PS-OC网络的整合以及其教育和推广任务。内部物理肿瘤学接口委员会将提供额外的指导和机构支持。CAC职责的一个关键方面将是发展试点和跨网项目，以进一步实现4DB中心的研究目标，并补充其他PS-OC网络中心的研究。项目经理Enrique Abola将负责中心的日常运营，并向dr。Kuhn和Bethel，他们负责与PS-OCs指导委员会（PSC）的沟通和互动。4DB中心的数据共享和通信将通过一个企业级软件系统集成，该软件系统由数据库系统、门户网站和用于数据/样本跟踪和数据注释/协作的独立软件程序组成。

DESCRIPTION (provided by applicant): The 4DB Center will be directed by the PI, Peter Kuhn (physics), who will be assisted by senior co-investigator Kelly Bethel (oncology). Both are voting members of the Center Advisory Committee (CAC) and will be joined by John Griffin (hematology) and Paul Newton (mathematics/physics). Along with four external scientific advisors as non-voting members and an NCI representative, they will oversee all programmatic and organizational aspects of the Center, its integration with the PS-OC Network and its education and outreach mission. An internal physics oncology interface board will provide additional guidance and institutional support. A key aspect of the CAC's responsibilities will be the development of pilot and trans-network projects to further the 4DB Center research goals as well as to complement the research of the other PS-OC Network centers. The project manager, Enrique Abola, will be responsible for the day-to-day center operations and will report to Drs. Kuhn and Bethel, who are responsible for communication and interaction with the PS-OCs Steering Committee (PSC). The 4DB Center data sharing and communication will be integrated through an enterprise-class software system consisting of a database system, web portal and standalone software programs for data/sample tracking and data annotation/collaboration.