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The Transcription Factor SLUG may Drive the Progression of Akt and HER2/neu

The Transcription Factor SLUG may Drive the Progression of Akt and HER2/neu
转录因子 SLUG 可能驱动 Akt 和 HER2/neu 的进展
批准号:
7847272
负责人:
DENNIS J SLAMON
金额:
$3.81万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-09-01 至 2012-08-31
关键词:
African AmericanAntibodiesBiological FactorsBiological MarkersBiological TestingBiotechnologyBreastBreast Cancer CellCancer CenterCancer PatientCancer cell lineCandidate Disease GeneCell Adhesion MoleculesCell LineCell modelCell-Cell AdhesionCellsClinicalClinical TrialsCohort StudiesCultured CellsDataDiseaseDisease OutcomeDisease-Free SurvivalDoctor of MedicineDoctor of PhilosophyDown-RegulationDrug resistanceE-CadherinERBB2 geneEconomic FactorsEpithelialEpithelial CellsEthnic OriginFamilyFreezingFutureGene ProteinsGenesGrowthHispanicsIn VitroInsuranceLaboratoriesLatinaLeadMCF7 cellMalignant NeoplasmsMammary NeoplasmsMammary glandMedicalMentorsMesenchymalMessenger RNAMethodsMicroarray AnalysisMinorityModelingMolecular TargetNamesNeoplasm MetastasisNormal CellOutcomeOutcome StudyPTEN geneParaffinPathogenesisPathway interactionsPatientsPlayPopulationPostdoctoral FellowPredictive ValuePrincipal InvestigatorRaceRecurrenceRegulationResearchResearch DesignResearch PersonnelResistanceResourcesReverse Transcriptase Polymerase Chain ReactionRiskRoche brand of trastuzumabRoleSKBR3SalmonSample SizeSamplingScientistSignal PathwaySignal TransductionSiteSlideSmall Interfering RNASnailsSpecificitySystemTestingTherapeutic InterventionTimeTissuesTransfectionTransgenic MiceTrastuzumabTumor SubtypeTumor TissueUnderrepresented MinorityUnderserved PopulationUniversitiesUp-RegulationWomanabstractingcancer health disparitycancer stem cellcell motilitychemotherapyclinically significantepithelial to mesenchymal transitionerbB-2 Receptorestablished cell lineexperiencehealth care qualityimprovedin vitro Modelin vivoinhibitor/antagonistinterestmalignant breast neoplasmmortalitymouse modelneoplastic cellnoveloverexpressionpreventprognosticreceptorrepositoryresponseself-renewalslugstem cell differentiationtherapy resistanttissue culturetranscription factortumortumor progressionwortmannin

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CRU - Clinical Research Unit Shared Resource
HER-2/NEU ALTERATIONS IN BREAST AND OVARIAN CANCER
PHASE I STUDY IN PATIENTS WITH PERITONEAL CARCINOMATOSIS USING SCH58500
ADVANCES IN HUMAN BREAST AND PROSTATE CANCER
  • 批准号:
    6083956
  • 项目类别:
  • 资助金额:
    $0.9万
  • 财政年份:
    2000
  • 负责人:
    DENNIS J SLAMON
  • 依托单位:
海外基金