METABOLISM OF A HETEROCYCLIC AMINE COLON CARCINOGEN IN YOUNG AND OLD RATS

杂环胺结肠致癌物在幼鼠和老年大鼠中的代谢

• 批准号: 7953976
• 负责人: HARVEY JAMES ARMBRECHT
• 金额: $ 0.16万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953976
• 关键词: Age; Animals; Carcinogens; Colon Carcinoma; Computer Retrieval of Information on Scientific Projects Database; Cytochrome P450; Funding; Genus Cola; Grant; Heterocyclic Amines; Inbred F344 Rats; Incidence; Injection of therapeutic agent; Institution; Mass Spectrum Analysis; Meat; Metabolism; Pharmaceutical Preparations; Radiolabeled; Rattus; Research; Research Personnel; Resources; Source; United States National Institutes of Health; biomedical resource; male; quinoline; radiotracer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The incidence of colon cancer increases with age, and this may be related to altered metabolism and disposition of carcinogens. One such carcinogen implicated in colon cancer is the heterocyclic amine found in well done meat, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). The purpose of these studies was to determine whether the disposition and metabolism of IQ changes with age, comparing young (3-month) and old (22- to 24-month) male F344 rats. Animals were treated with vehicle or beta-naphthoflavone (BNF), an inducer of drug-metabolizing cytochromes P450. Disposition and metabolism of IQ were determined after i.p. injection of radiolabeled IQ.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 结肠癌的发病率随着年龄的增长而增加，这可能与致癌物代谢和处置的改变有关。与结肠癌有关的一种致癌物质是熟肉中发现的杂环胺，即 2-氨基-3-甲基咪唑并[4,5-f]喹啉 (IQ)。这些研究的目的是通过比较年轻（3 个月）和老年（22 至 24 个月）雄性 F344 大鼠，确定智商的分布和代谢是否随年龄变化。用载体或β-萘黄酮（BNF）（一种药物代谢细胞色素 P450 的诱导剂）治疗动物。腹腔注射后测定智商的分布和代谢。注射放射性标记的 IQ。