Virus specific memory T cell responses in H5N1 avian influenza virus infected patients

H5N1禽流感病毒感染患者的病毒特异性记忆T细胞反应

• 批准号: G0600520/1
• 负责人: Tao Dong
• 金额: $ 53.27万
• 依托单位: Medical Research Council
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600520%2F1
• 关键词: Virus; specific; memory; cell; responses

The aim of this study is to study how the human body can respond to avian influenza virus infection, focusing specifically on white blood cells (called killer T-cells) that kill influenza-virus-infected cells. We will ask how big are these T cell responses and do they react only to avian virus or will people whose T-cells recognise the common flu strains have some protection against avian flu? Do these T-cell responses play a part in protecting people who have been exposed to avian flu but who did not become sick? Or is there a possibility that having T-cell immunity to the more common influenza virus strains could actually cause disease in people who are exposed to avian strains of influenza A virus?

这项研究的目的是研究人体如何应对禽流感病毒的感染，特别是专注于杀死流感病毒感染细胞的白细胞(称为杀手T细胞)。我们会问这些T细胞反应有多大，它们是只对禽流感病毒反应，还是T细胞识别常见流感病毒的人对禽流感有一定的保护作用？这些T细胞反应在保护那些接触过禽流感但没有患病的人方面起到了作用吗？或者，有没有可能，对更常见的流感病毒株具有T细胞免疫力，实际上可能会导致接触A型流感病毒的人患病？