NUTRIENT INGESTION, PROTEIN INTAKE, AND SEX, BUT NOT AGE, AFFECT THE ALBUMIN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是评估营养素摄入、膳食蛋白摄入、年龄和性别对白蛋白合成率（FSR）的影响。36个健康自由生活的人（8名女性和10名男性，年龄为21-43岁，9名女性和9名男性，年龄为63-79岁）完成了三个18天的控制喂养期，蛋白质摄入量为125%，（P125，1.00 g蛋白质x kg（-1）x d（-1））、94%（P94，0.75 g蛋白质x kg（-1）x d（-1））和63%（P63，0.50 g蛋白质x kg（-1）x d（-1））的推荐膳食供给量。在每项试验的第12天，测定吸收后（PA）血清白蛋白浓度，并根据8小时输注期间L-[1- 13 C]亮氨酸掺入血浆白蛋白的速率估计PA和餐后（PP）白蛋白FSR。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this study was to assess the effects of nutrient ingestion, dietary protein intake, age, and sex on the fractional synthesis rate (FSR) of albumin. Thirty-six healthy free-living individuals (8 females and 10 males aged 21-43 y and 9 females and 9 males aged 63-79 y) completed three 18-d periods of controlled feeding with protein intakes of 125% (P125, 1.00 g protein x kg(-1) x d(-1)), 94% (P94, 0.75 g protein x kg(-1) x d(-1)), and 63% (P63, 0.50 g protein x kg(-1) x d(-1)) of the recommended dietary allowance. On d 12 of each trial, postabsorptive (PA) serum albumin concentration was determined and PA and postprandial (PP) albumin FSR were estimated from the rate of l-[1- 13C] leucine incorporation into plasma albumin during an 8-h infusion.