NUTRIENT INGESTION, PROTEIN INTAKE, AND SEX, BUT NOT AGE, AFFECT THE ALBUMIN

营养摄入、蛋白质摄入和性别会影响白蛋白，但年龄不会

• 批准号: 7953992
• 负责人: Anna E. Thalacker-Mercer
• 金额: $ 1.4万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953992
• 关键词: 21 year old; Affect; Age; Albumins; Computer Retrieval of Information on Scientific Projects Database; Dietary Proteins; Female; Funding; Grant; Individual; Infusion procedures; Ingestion; Institution; Intake; Leucine; Life; Mass Spectrum Analysis; Nutrient; Plasma Albumin; Proteins; Recommended Dietary Allowance; Research; Research Personnel; Resources; Serum Albumin; Source; United States National Institutes of Health; aged; biomedical resource; feeding; male; sex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this study was to assess the effects of nutrient ingestion, dietary protein intake, age, and sex on the fractional synthesis rate (FSR) of albumin. Thirty-six healthy free-living individuals (8 females and 10 males aged 21-43 y and 9 females and 9 males aged 63-79 y) completed three 18-d periods of controlled feeding with protein intakes of 125% (P125, 1.00 g protein x kg(-1) x d(-1)), 94% (P94, 0.75 g protein x kg(-1) x d(-1)), and 63% (P63, 0.50 g protein x kg(-1) x d(-1)) of the recommended dietary allowance. On d 12 of each trial, postabsorptive (PA) serum albumin concentration was determined and PA and postprandial (PP) albumin FSR were estimated from the rate of l-[1- 13C] leucine incorporation into plasma albumin during an 8-h infusion.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是评估营养摄入，饮食蛋白摄入，年龄和性别对白蛋白分数合成率（FSR）的影响。 36个健康的自由生活个体（8个女性和10名男性21-43岁和9名女性和9名年龄63-79岁的男性）完成了3个18-D时期，蛋白质摄入量为125％（p125，1.00 G蛋白X kg（-1）x d（-1）x D（-1）x D（-1），94％（p94％）（P125，1.00 G蛋白d（-1））和63％（p63，0.50 g蛋白x kg（-1）x d（-1））的建议饮食津贴。在每次试验的D 12中，确定了次吸收（PA）血清白蛋白浓度，并从8-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-H-[1-13C]亮氨酸掺入速率中估算PA和PA和餐后（PP）白蛋白FSR。