Identification and quantification of HIV Latency biomarkers in the Central Nervous System

中枢神经系统中 HIV 潜伏期生物标志物的鉴定和定量

• 批准号: nhmrc : 1105808
• 负责人: Dr Lucette Cysique
• 金额: $ 56.05万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-quantification-hiv-central-nervous/662860
• 关键词: Identification; quantification; HIV; Latency; biomarkers

One major obstacle in curing HIV is the brain’s role as a potential reservoir of HIV infection. It is unknown if “reawakening” of HIV may lead to uncontrollable brain damage given that current antiretroviral drugs vary in their ability to treat brain infection. Not all patients have HIV brain infection so eradication therapies in themselves may be safe. We aim to identify and quantify biomarkers of HIV latency in the brain to stratify patients into these two cohorts.

治疗HIV的一个主要障碍是大脑作为HIV感染的潜在储存库的作用。目前尚不清楚艾滋病毒的“重新唤醒”是否会导致无法控制的脑损伤，因为目前的抗逆转录病毒药物治疗脑感染的能力各不相同。并非所有患者都有HIV脑感染，因此根除疗法本身可能是安全的。我们的目标是识别和量化大脑中艾滋病毒潜伏期的生物标志物，以将患者分为这两个队列。