Investigation into the role of phosphatidylinositol 3,5-bisphosphate and AP-1 in multivesicular body protein sorting

每一种动物都是由精确排列的叫做细胞的小构件组成的。每个细胞的内部都是高度组织化的。在细胞内，各种机制对包括蛋白质在内的成分进行分类，并将它们送到正确的隔室。蛋白质分选对许多过程至关重要，包括控制细胞分裂和免疫和神经系统的正确功能。这些过程中的缺陷会导致疾病。像HIV这样的病毒接管了蛋白质分选所需的细胞机制，并利用它逃离细胞。酵母细胞系统的研究已经获得了关于蛋白质分选的重要信息，因为酵母细胞具有所有（包括人类）细胞共同的基本细胞机制，并且它们快速生长且易于操作。我们的工作，利用酵母细胞系统，旨在了解一个特定的细胞蛋白质分类系统是如何运作的。从这项研究中获得的结果将提供关于蛋白质分选的基本机制的信息，为了开发各种人类疾病的有效治疗，必须了解蛋白质分选的基本机制。

Every animal is made up of precisely arranged small building blocks called cells. The inside of each cell is highly organized. Within the cell, mechanisms sort the components, including proteins, and send them to the correct compartments. Protein sorting is essential for many processes including the control of cell division and correct functioning of the immune and nervous systems. Defects in these processes can lead to disease. Viruses such as HIV take over the cellular machinery required for protein sorting, and use it to escape from the cell. Studies of the yeast cell system have yielded important information on protein sorting, as yeast cells have the basic cellular machinery common to all (including human) cells, and they are fast-growing and easy to manipulate. Our work, using the yeast cell system, aims to understand how one particular cellular protein sorting system functions. The results obtained from this study will provide information about the basic mechanisms of protein sorting which must be understood in order to develop effective treatments for a variety of human diseases.