Investigation into the role of phosphatidylinositol 3,5-bisphosphate and AP-1 in multivesicular body protein sorting

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Every animal is made up of precisely arranged small building blocks called cells. The inside of each cell is highly organized. Within the cell, mechanisms sort the components, including proteins, and send them to the correct compartments. Protein sorting is essential for many processes including the control of cell division and correct functioning of the immune and nervous systems. Defects in these processes can lead to disease. Viruses such as HIV take over the cellular machinery required for protein sorting, and use it to escape from the cell. Studies of the yeast cell system have yielded important information on protein sorting, as yeast cells have the basic cellular machinery common to all (including human) cells, and they are fast-growing and easy to manipulate. Our work, using the yeast cell system, aims to understand how one particular cellular protein sorting system functions. The results obtained from this study will provide information about the basic mechanisms of protein sorting which must be understood in order to develop effective treatments for a variety of human diseases.