Superantigen Interactions in Streptococcal Tonsillitis

链球菌扁桃体炎中的超抗原相互作用

基本信息

  • 批准号:
    G0601399/1
  • 负责人:
  • 金额:
    $ 28.67万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Fellowship
  • 财政年份:
    2007
  • 资助国家:
    英国
  • 起止时间:
    2007 至 无数据
  • 项目状态:
    已结题

项目摘要

Streptococcus pyogenes is the major cause of bacterial tonsillitis worldwide, and is also responsible for severe invasive infections such as necrotising fasciitis and toxic shock syndrome. Although it can cause severe infections, S. pyogenes can also be carried asymptomatically in the throat, and transferred from person to person. It is known that S. pyogenes produces a number of highly potent toxins (superantigens), which have the ability to create a massive inflammatory response, and can even overwhelm the immune system. However, it is unclear why or when these are produced by the bacteria.This research will investigate the role of the superantigens produced by S. pyogenes in tonsillitis. Using a variety of laboratory techniques we will see if the superantigens alone are responsible for the inflammatory changes which occur during tonsil infections, and whether their production is increased in bacteria cultured from people with clinical disease when compared to their relatives who have asymptomatic carriage of the same bacterial strain.The results of this study will not only provide important information about the mechanisms employed by S. pyogenes to cause disease, but can also be applied to other bacteria which produce superantigens, especially Staphylococcus aureus.
化脓性链球菌是世界范围内细菌性扁桃体炎的主要病因,也是严重侵袭性感染的原因,如坏死性筋膜炎和中毒性休克综合征。虽然它可以引起严重的感染,但化脓性链球菌也可以在喉咙中无症状地携带,并在人与人之间传播。众所周知,化脓性链球菌会产生许多强效毒素(超级抗原),这些毒素有能力产生大量的炎症反应,甚至可以压倒免疫系统。然而,目前尚不清楚这些细菌产生的原因和时间。本研究将探讨化脓性链球菌产生的超级抗原在扁桃体炎中的作用。使用各种实验室技术,我们将看到超级抗原是否单独负责扁桃体感染期间发生的炎症变化,以及与无症状携带相同菌株的亲属相比,从临床疾病患者培养的细菌中产生的超级抗原是否增加。本研究结果不仅为化脓性葡萄球菌致病机制提供了重要信息,而且也可应用于其他产生超抗原的细菌,特别是金黄色葡萄球菌。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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Frances Davies其他文献

Streptococcus pyogenes superantigen SPEA expression suppresses all immunoglobulin classes in human tonsil explants
  • DOI:
    10.1016/j.jinf.2010.09.009
  • 发表时间:
    2010-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    Frances Davies;Claire Turner;Joseph Boyle;Shiranee Sriskandan
  • 通讯作者:
    Shiranee Sriskandan
Aminoglycoside heteroresistance in emEnterobacter cloacae/em is driven by the cell envelope stress response
阴沟肠杆菌中的氨基糖苷类异质性耐药是由细胞包膜应激反应驱动的
  • DOI:
    10.1128/mbio.01699-24
  • 发表时间:
    2024-11-13
  • 期刊:
  • 影响因子:
    4.700
  • 作者:
    Ana J. Choi;Daniel J. Bennison;Esha Kulkarni;Hibah Azar;Haoyu Sun;Hanqi Li;Jonathan Bradshaw;Hui Wen Yeap;Nicholas Lim;Vishwas Mishra;Anna Crespo-Puig;Ewurabena A. Mills;Frances Davies;Shiranee Sriskandan;Avinash R. Shenoy
  • 通讯作者:
    Avinash R. Shenoy
811 FECAL MICROBIOTA TRANSPLANT PRIOR TO ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT IN PATIENTS COLONIZED WITH MULTI-DRUG RESISTANT ORGANISMS IS ASSOCIATED WITH IMPROVED SURVIVAL
  • DOI:
    10.1016/s0016-5085(21)01156-2
  • 发表时间:
    2021-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Benjamin H. Mullish;Andrew J. Innes;Rohma Ghani;Richard Szydlo;Horace R. Williams;Mark R. Thursz;Julian Marchesi;Frances Davies;Jiri Pavlu
  • 通讯作者:
    Jiri Pavlu
1144 FECAL MICROBIOTA TRANSPLANT FOR MULTI-DRUG RESISTANT ORGANISMS: IMPROVED CLINICAL OUTCOMES BEYOND INTESTINAL DECOLONISATION
  • DOI:
    10.1016/s0016-5085(20)31256-7
  • 发表时间:
    2020-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Rohma Ghani;Benjamin H. Mullish;Julie A. McDonald;Anan Ghazy;Horace R. Williams;Eimear Brannigan;Giovanni Satta;Mark Gilchrist;Neill Duncan;Richard Corbett;Jiri Pavlu;Andrew J. Innes;Mark R. Thursz;Frances Davies;Julian Marchesi
  • 通讯作者:
    Julian Marchesi
894: RELATIVE CHANGE OF <em>ENTEROCOCCUS FAECIUM</em>, SELECTED COMMENSAL BACTERIA AND CYTOKINES ARE SEEN IN PATIENTS COLONIZED WITH MULTIDRUG-RESISTANT ORGANISMS WHO UNDERGO INTESTINAL MICROBIOTA TRANSPLANTATION.
  • DOI:
    10.1016/s0016-5085(22)60523-7
  • 发表时间:
    2022-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Rohma Ghani;Jesús Miguéns Blanco;Roberta Forlano;Evangelos Triantafyllou;Jaroslaw Bilinski;Naama Geva-Zatorsky;Haggai Bar-Yoseph;Mark R. Thursz;Frances Davies;Benjamin H. Mullish;Julian Marchesi
  • 通讯作者:
    Julian Marchesi

Frances Davies的其他文献

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{{ truncateString('Frances Davies', 18)}}的其他基金

Epidemiological and genetic investigations into carbapenem resistance caused by horizontal gene transfer within hospitals.
对医院内水平基因转移引起的碳青霉烯类耐药性的流行病学和遗传学调查。
  • 批准号:
    MR/T005254/1
  • 财政年份:
    2019
  • 资助金额:
    $ 28.67万
  • 项目类别:
    Research Grant

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