Functional characterisation of the major susceptibility locus (PSORS1) for cutaneous inflammation in psoriasis

银屑病皮肤炎症主要易感位点 (PSORS1) 的功能特征

• 批准号: G0601387/1
• 负责人: Richard Trembath
• 金额: $ 198.92万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0601387%2F1
• 关键词: Functional; characterisation; major; susceptibility; locus

Skin presents an essential barrier to environmental triggers capable of preventing challenge to the bodies natural defence mechanisms which includes a sophisticated immune surveillance network. Psoriasis, a life long skin disorder, is amongst a group of common conditions associated with chronic irritation and inflammation. Available evidence points to a fundamental defect in the capacity for barrier protection, dysregulation of the immune network or a combination of these through abnormal communication between skin and immune pathways. In order to develop new and effective therapies, a clear understanding of these processes and the fundamental defects that characterise the risk of developing psoriasis is now required. From a well defined region of the human genome, we have set out a series of studies designed to characterise the primary alterations that generate a very much increased risk disease development. Progress towards more effective ways to prevent or cure psoriasis would be expected to cut both in the short and long term, the heavy burden of chronic inflammation, and thus lead to a significant health and economic benefits compared to the present management of this disorder.

皮肤是环境触发的重要屏障，能够防止对身体自然防御机制的挑战，其中包括复杂的免疫监视网络。牛皮癣是一种终身皮肤病，是一组与慢性刺激和炎症相关的常见疾病。现有证据表明，屏障保护能力存在根本缺陷，免疫网络失调或通过皮肤和免疫途径之间的异常交流而导致的这些缺陷的组合。为了开发新的和有效的治疗方法，现在需要清楚地了解这些过程和降低发展银屑病风险的基本缺陷。从人类基因组的一个明确定义的区域，我们已经制定了一系列的研究，旨在确定主要的改变，产生一个非常增加的风险疾病的发展。朝着更有效的方法来预防或治疗银屑病的进展将有望在短期和长期内减少慢性炎症的沉重负担，从而与目前对这种疾病的管理相比，带来显着的健康和经济效益。