Corticosteroids, Intracranial Pressure and the Pathogenesis of Idiopathic Intracranial Hypertension.

皮质类固醇、颅内压和特发性颅内高压的发病机制。

• 批准号: G0601430/1
• 负责人: Alexandra Sinclair
• 金额: $ 26.08万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0601430%2F1
• 关键词: Corticosteroids; Intracranial; Pressure; Pathogenesis; Idiopathic

Idiopathic intracranial hypertension, (IIH), is a common blinding condition in overweight women. Affected patients suffer with severe headaches and significant visual loss resulting from increased brain pressure, called intracranial pressure. The cause of raised brain pressure in IIH is not known, but it is likely to relate to abnormalities in the balance between production and drainage of brain fluid, known as cerebrospinal fluid (CSF). As greater than 90% of IIH patients are female and obese we expect that the disordered CSF balance may relate to hormones and obesity, our study will investigate this further. Initially, we will identify where and how these hormones act in the areas of the brain that are known to produce and drain CSF. We will then study the urine, serum and CSF of patients with IIH to determine which hormones and chemicals are unique to the disease. Finally, weight loss has previously been suggested as a treatment for IIH, but to date this has not been proven. A clinical study will be carried out to identify whether weight loss is truly effective in treating IIH, and if so whether this works by altering disease specific hormone levels.

特发性颅内高压（IIH）是超重女性中一种常见的致盲疾病。受影响的患者会因颅内压升高而遭受严重的头痛和严重的视力丧失。IIH患者脑压升高的原因尚不清楚，但可能与脑脊液（CSF）产生和排出之间的平衡异常有关。由于超过90%的IIH患者为女性且肥胖，我们预计脑脊液平衡紊乱可能与激素和肥胖有关，我们的研究将进一步探讨这一点。首先，我们将确定这些激素在大脑中产生和排出脑脊液的区域的位置和作用方式。然后，我们将研究IIH患者的尿液、血清和脑脊液，以确定哪些激素和化学物质是这种疾病所特有的。最后，减肥以前曾被认为是治疗IIH的一种方法，但迄今为止还没有得到证实。将进行一项临床研究，以确定减肥是否真的对治疗IIH有效，如果有效，是否通过改变疾病特异性激素水平起作用。