11 beta-hydroxysteroid dehydrogenase type 1, growth hormone and the pathophysiology of age related sarcopaenia

11 β-羟基类固醇脱氢酶 1 型、生长激素和年龄相关性肌少症的病理生理学

• 批准号: G0601429/1
• 负责人: Mark Sherlock
• 金额: $ 40.94万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0601429%2F1
• 关键词: 11; beta; hydroxysteroid; dehydrogenase; type

With increasing age the body changes in a number of ways including a decrease in muscle mass, increase in abdominal fat and a decrease in bone density. A number of hormones in the blood also change with increasing age. One of the main hormones that decrease with age is growth hormone. Patients who have low growth hormone or too much steroids in their body have very similar changes in body shape to those which occur with ageing. We believe that the changes that occur in body shape and muscle with ageing are due to a decrease in growth hormone and a relative increase in steroid levels in the body‘s tissues. This study aims to look at the levels and role of these hormones directly in human muscle tissue. This will involve blood and urine samples and a taking a small piece of muscle tissue from the thigh of these patients. People who take part will also assessment of body fat and muscle mass and muscle strength. This study will help us understand further the effects of hormones on the ageing process.

随着年龄的增长，身体在许多方面发生变化，包括肌肉质量减少，腹部脂肪增加和骨密度降低。血液中的一些激素也随着年龄的增长而变化。随着年龄的增长而减少的主要激素之一是生长激素。体内生长激素水平低或类固醇过多的患者，其体型变化与衰老时发生的变化非常相似。我们认为，随着年龄的增长，身体形状和肌肉发生的变化是由于生长激素的减少和身体组织中类固醇水平的相对增加。这项研究旨在直接研究这些激素在人体肌肉组织中的水平和作用。这将涉及血液和尿液样本，并从这些患者的大腿上取一小块肌肉组织。参加的人也将评估身体脂肪和肌肉质量和肌肉力量。这项研究将有助于我们进一步了解激素对衰老过程的影响。