Glucocorticoid regulation of interleukin 8 expression in chronic obstructive pulmonary disease

糖皮质激素对慢性阻塞性肺疾病白细胞介素8表达的调节

• 批准号: G0601556/1
• 负责人: John Blaikley
• 金额: $ 28.47万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0601556%2F1
• 关键词: Glucocorticoid; regulation; interleukin; expression; chronic

Chronic obstructive pulmonary disease (COPD) is an inflammatory lung condition and a major cause of deaths worldwide. Since it is an inflammatory disease antiinflamatory medication such as steroids should be effective. However steroids usually fail to improve the COPD disease course significantly. This clinically observed resistance to steroid treatment is likely to be important for understanding the basis of the disease itself, and also for the clinical management of patients.We are, therefore, currently investigating steroid action in COPD. We are doing this by comparing inflammatory lung cells between COPD patients and healthy volunteers. Interleukin 8 is a critical signal for recruitment of inflammatory cells to the lung, and is expressed at high level in COPD. Interleukin 8 is typically inhibited by glucocorticoids; but this effect is lost in COPD, contributing to their lack of beneficial effect. We will discover why interleukin 8, in COPD, acquires resistance to glucocorticoid inhibition. This will indicate new approaches to COPD treatment.

慢性阻塞性肺疾病（COPD）是一种炎症性肺部疾病，也是全球死亡的主要原因。由于它是一种炎症性疾病，抗炎药物如类固醇应该是有效的。然而，类固醇通常不能显著改善COPD病程。这种临床观察到的对类固醇治疗的耐药性对于了解疾病本身的基础以及对患者的临床管理可能是重要的，因此，我们目前正在研究类固醇在COPD中的作用。我们通过比较COPD患者和健康志愿者之间的炎症肺细胞来做到这一点。白细胞介素8是炎症细胞向肺募集的关键信号，并且在COPD中以高水平表达。白细胞介素8通常被糖皮质激素抑制;但这种作用在COPD中丧失，导致其缺乏有益作用。我们将发现为什么COPD患者的白细胞介素8对糖皮质激素抑制产生抵抗。这将为COPD治疗提供新的方法。