CEQUEL-FA: Comparative evaluation of quetiapine plus lamotrigine vs quetiapine monotherapy, and folic acid vs placebo

双相抑郁症患者有相当大的治疗需求未得到满足，这意味着他们经常遭受持续的症状和残疾。第一次，有希望的药物治疗正在出现，但我们需要知道如何最好地利用它们来帮助人们。我们将进行一项随机临床试验，研究喹硫平和拉莫三嗪的联合使用，这将有助于临床医生和患者选择治疗双相情感障碍抑郁症状的最佳方法。我们还将研究叶酸——一种天然存在的维生素——是否可能改善症状

People with bipolar depression have considerable unmet treatment needs whcih means that they often suffer from continuing symptoms and disability. For the first time, promising drug treatments are now emerging, but we need to know how they can best ben used to help people. We will do a randomised clinical trial investigating the combination of quetiapine and lamotrigine which will help clinicians and patients to choose the best treatment for depressive symptoms in bipolar disorder. We will also investigate the possibility that folic acid - a naturally occurring vitamin - will improve symptoms