Human cytomegalovirus latency, reactivation and immune control

人类巨细胞病毒潜伏期、再激活和免疫控制

• 批准号: G0701279/1
• 负责人: John Sinclair
• 金额: $ 213.93万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701279%2F1
• 关键词: Human; cytomegalovirus; latency; reactivation; immune

Human cytomegalovirus (HCMV) is a virus which is carried without symptoms by the majority of the population. However, it can cause serious disease in infants born to mothers who acquire the infection in pregnancy and in people whose immune system is suppressed. Understanding how the virus succeeds in maintaining itself in most people without causing disease and how this relationship breaks down to cause disease should help develop better methods of treating the virus and of designing a vaccine (there is currently no vaccine available). Our research is aimed at determining (i) the mechanism by which the virus maintains silent infection (latency) in specialised cells of the immune system and the factors that reawake it and (ii) how the immune system controls the infection in normal people. In addition to advancing our understanding of HCMV in particular, this research may also lead to a better understanding of other virus infections which persist in the body, and how the human host controls them.

人巨细胞病毒（HCMV）是一种病毒，大多数人携带时没有症状。然而，它可能会导致严重的疾病，婴儿出生的母亲谁获得感染怀孕和人的免疫系统受到抑制。了解病毒如何成功地在大多数人体内维持自身而不引起疾病，以及这种关系如何破坏而引起疾病，应该有助于开发更好的治疗病毒和设计疫苗的方法（目前没有可用的疫苗）。我们的研究旨在确定（i）病毒在免疫系统的专门细胞中保持沉默感染（潜伏期）的机制以及重新唤醒它的因素，以及（ii）免疫系统如何控制正常人的感染。除了特别是促进我们对HCMV的理解外，这项研究还可能导致更好地了解在体内持续存在的其他病毒感染，以及人类宿主如何控制它们。