Developing the WTCRF in Cambridge: Magnetic Resonance Spectroscopy and a Nutrition Resource & Appetite Laboratory

在剑桥开发 WTCRF：磁共振波谱学和营养资源

• 批准号: G0701532/1
• 负责人: V Krishna K Chatterjee
• 金额: $ 32.74万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701532%2F1
• 关键词: Developing; WTCRF; Cambridge; Magnetic; Resonance

A Wellcome Trust-funded Clinical Research Facility (WTCRF) in Cambridge has been inoperation for several years at a high level (75%) of occupancy. Over 200 projects have beenundertaken, ranging from experimental medicine (where intensive patient investigation leads tounderstanding of disease mechanisms) to trials of treatment. Obesity, Diabetes and InsulinResistance are epidemic worldwide and internationally-recognised research programs inCambridge investigate genetic forms of obesity and insulin resistance, population diabetes,diabetes in childhood, critical illness & metabolism and metabolic storage diseases. Uniquely,our WTCRF contains specialised technologies (e.g.energy expenditure measurement) that arevital for such research and is also the locus for treatment trials (e.g replacement of leptin (anappetite hormone) in obesity or enzymes in storage diseases; prevention of diabetes).Magnetic resonance spectroscopy (MRS), technology which allows substances and metabolicpathways in tissues to be measured non-invasively and non-radioactively, has significantlyadvanced knowledge of metabolic disorders including diabetes. Support for an MRS scannertogether with specialist support staff, located within an expanded,existing imaging facility, willadd significantly to our metabolic research programs,with MRS measurements discoveringdisease mechanisms & monitoring treatment response in trials. Energy (food) intake is animportant variable in both specialised (e.g. obesity) or general clinical research, and existingCRF technologies for measuring this are rudimentary. Addition of a CRF Nutrition Resource(staff, diet kitchen) will enable dietary intake of research subjects to be either standardised oraltered in a defined way. An “appetite laboratory”, or mobile apparatus to measurecharacteristics of eating behaviour, is essential for research of obesity and other appetitedisorderedstates.

位于剑桥的一家由威康信托基金 (Wellcome Trust) 资助的临床研究机构 (WTCRF) 多年来一直处于闲置状态，入住率高达 75%。已经开展了 200 多个项目，从实验医学（深入的患者调查有助于了解疾病机制）到治疗试验。肥胖、糖尿病和胰岛素抵抗是世界范围内的流行病，剑桥国际公认的研究项目调查肥胖和胰岛素抵抗的遗传形式、人群糖尿病、儿童糖尿病、危重疾病和代谢以及代谢储存疾病。独特的是，我们的 WTCRF 包含对此类研究至关重要的专业技术（例如能量消耗测量），也是治疗试验的场所（例如在肥胖症中替代瘦素（食欲激素）或储存疾病中的酶；预防糖尿病）。磁共振波谱 (MRS) 技术允许物质和代谢途径 以非侵入性和非放射性方式测量的组织，对包括糖尿病在内的代谢性疾病具有显着的先进知识。对 MRS 扫描仪的支持以及位于扩展的现有成像设施内的专家支持人员的支持，将显着增强我们的代谢研究计划，通过 MRS 测量发现疾病机制并监测试验中的治疗反应。能量（食物）摄入量在专业（例如肥胖）或一般临床研究中都是一个重要变量，而现有的用于测量能量（食物）摄入量的 CRF 技术还处于初级阶段。增加 CRF 营养资源（工作人员、饮食厨房）将使研究对象的饮食摄入量能够以明确的方式标准化口头表达。 “食欲实验室”或测量饮食行为特征的移动设备对于肥胖和其他食欲紊乱状态的研究至关重要。