COBRE: UL: CELL INSTRINSIC MECHANISMS REGULATING SENSORY AXON REGENERATION

COBRE：UL：调节感觉轴突再生的细胞固有机制

• 批准号: 7959677
• 负责人: CHRISTOPHER B SHIELDS
• 金额: $ 24.27万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959677
• 关键词: Cells; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Consult; Data; Development; Digestion; Dorsal; Funding; Grant; Institution; Neurites; Neurons; Recovery of Function; Research; Research Personnel; Resources; Role; Sensory; Source; Staging; Testing; United States National Institutes of Health; Work; axon growth; axon regeneration; base; combinatorial; dorsal column; programs; repaired; transcription factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our specific aims have changed based on new data that we obtained. After consulting with the Program Director, we will test the hypothesis that intrinsic mechanisms for axon growth is programmed in the developmental stage and turned off after CNS maturation. We are attempting to rejuvenate this mechanism by modulation of Id2 and SnoN transcription factors that may promote axonal regeneration after SCI. As a result of the data outlined below, this work has been submitted to the NIH as an R01 Feb 08. Aim 1: Determine the role of Id2 in neurite sprouting from DRG neurons, as well as axon regeneration in the dorsal columns following a T8 dorsal hemisection. Aim 2: Determine the role of SnoN in neurite sprouting, and axon regeneration following T8 dorsal hemisection. Aim 3: Explore combinatorial strategies using CSPG digestion and MPI blocking to maximize axon regeneration and functional recovery following SCI.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 根据我们获得的新数据，我们的具体目标发生了变化。 在与项目主任协商后，我们将测试轴突生长的内在机制在发育阶段被编程并在CNS成熟后关闭的假设。我们正试图通过调节Id 2和SnoN转录因子来恢复这种机制，这些转录因子可能促进SCI后的轴突再生。 根据下文列出的数据，本研究已作为R 01（2008年2月）提交给NIH。 目标1：确定Id 2在DRG神经元的神经突发芽中的作用，以及在T8背侧半切后背柱中的轴突再生。 目的2：确定SnoN在T8背侧半切后神经突发芽和轴突再生中的作用。 目的3：探索使用CSPG消化和MPI阻断的组合策略以最大化SCI后的轴突再生和功能恢复。