Brain anatomical correlates of mobility control in the oldest old

大脑解剖学与老年人活动控制的相关性

• 批准号: 7916475
• 负责人: Caterina Rosano
• 金额: $ 57.38万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916475
• 关键词: Address; African American; Age; Aged, 80 and over; Aging; Aging-Related Process; Area; Arthralgia; Atrophic; Attenuated; Basal Ganglia; Biological Neural Networks; Blood Pressure; Blood Vessels; Body Composition; Body mass index; Brain; Brodmann' s area; Cardiopulmonary; Cardiovascular system; Cells; Cerebellum; Cognition; Cognitive; Cohort Studies; Communities; Cross-Sectional Studies; Data Collection; Dementia; Diffusion Magnetic Resonance Imaging; Elderly; Epidemiology; Equilibrium; Funding; Gait; Goals; Health; Imaging Techniques; Impairment; Internal Capsule; Knowledge; Label; Limb structure; Link; Lobule; Location; Lower Extremity; Magnetic Resonance Imaging; Measures; Methods; Musculoskeletal; Natural History; Nature; Neuraxis; Neurological status; Neurons; Parietal; Parkinson Disease; Participant; Pathogenesis; Pathway interactions; Pattern; Peripheral; Phase; Physical activity; Prefrontal Cortex; Pulmonary Heart Disease; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Risk Factors; Severities; Spatial Distribution; Speed; Strategic Planning; Stroke; Structure; Time; Women' s Health; Work; age related; cardiovascular risk factor; cohort; follow-up; frontal lobe; gray matter; inflammatory marker; insight; muscle strength; nervous system disorder; programs; putamen; white matter

DESCRIPTION (provided by applicant): Community-dwelling older adults often report mobility impairment linked with multifactorial changes in the cardiopulmonary, musculoskeletal, peripheral and central nervous systems. There is strong emergent evidence that white matter (WM) hyperintensities are associated with lower-extremity mobility limitations independent of other factors. Dr. Rosano has recently discovered that impaired speed and balance are associated with focal grey matter (GM) atrophy of specific mobility-related regions. This longitudinal epidemiological project aims to investigate the longitudinal association of focal brain magnetic resonance imaging (MRI) abnormalities in GM and WM with age-related mobility impairment in gait speed and balance in a large cohort of community-dwelling older adults from the Health Aging Body Composition Study (Health ABC). This proposal builds onto the current ongoing Healthy Brain Project (K23AG028966-01, PI: Dr Rosano), which is a descriptive cross-sectional study of the association between quantitative brain MRIs measures and mobility in 250 participants of the Health ABC cohort. The new study that we propose will increase the power to detect important effects via the acquisition of additional 148 MRIs and will provide further longitudinal insights into the impact of brain MRI abnormalities on the natural history of mobility impairment by adding a follow up time of 3 years after completion of brain MRI. Thus, this proposal is uniquely timed to capture important information during the planned data collection phase of the Health ABC Study in 2006-2007. This project uses automated volumetric methods, magnetization transfer and diffusion tensor imaging to measure severity and location of GM and WM abnormalities. The aims of this project are: 1. To examine the longitudinal association of focal regional GM and WM tracts abnormalities with worsening mobility and specifically with gait speed and balance. 2. To examine the combined effect of groups of GM/ WM abnormalities on worsening speed and balance. 3. To determine the longitudinal association of cardiovascular risk factors with focal GM and WM abnormalities in mobility-related regions and tracts. The results of this project will advance our knowledge of the pathogenesis of mobility impairment in community-dwelling older adults and will lay the ground work for further studies of age-related changes of the neural networks involved in mobility control, for example using functional brain MRI studies.

描述（由申请人提供）：社区居住的老年人经常报告与心肺、肌肉骨骼、外周和中枢神经系统的多因素变化相关的行动障碍。有强有力的新证据表明，白质（WM）高信号与下肢活动受限相关，而与其他因素无关。 Rosano 博士最近发现，速度和平衡受损与特定活动相关区域的局灶性灰质 (GM) 萎缩有关。该纵向流行病学项目旨在调查来自健康老龄化身体成分研究 (Health ABC) 的一大群社区老年人中 GM 和 WM 的局灶性脑磁共振成像 (MRI) 异常与年龄相关的步态速度和平衡性运动障碍之间的纵向关联。该提案建立在当前正在进行的健康大脑项目（K23AG028966-01，PI：Rosano 博士）的基础上，该项目是一项描述性横断面研究，针对 Health ABC 队列的 250 名参与者进行定量脑 MRI 测量与活动能力之间的关联。我们提出的新研究将通过获取额外的 148 个 MRI 来提高检测重要影响的能力，并将通过在完成脑 MRI 后增加 3 年的随访时间，进一步纵向了解脑 MRI 异常对活动障碍自然史的影响。因此，该提案的时机非常独特，可以在 2006-2007 年 Health ABC 研究的计划数据收集阶段捕获重要信息。该项目使用自动体积方法、磁化转移和扩散张量成像来测量 GM 和 WM 异常的严重程度和位置。该项目的目标是： 1. 检查局灶性区域 GM 和 WM 束异常与活动能力恶化（特别是步态速度和平衡）之间的纵向关联。 2. 检查 GM/WM 异常组对速度和平衡能力恶化的综合影响。 3. 确定心血管危险因素与活动相关区域和束中局灶性 GM 和 WM 异常的纵向关联。该项目的结果将增进我们对社区老年人活动障碍发病机制的了解，并为进一步研究参与活动控制的神经网络与年龄相关的变化奠定基础，例如使用功能性脑 MRI 研究。