Inhibitory anti-CD3 antibodies to switch off activated T cells in man

抑制性抗 CD3 抗体可关闭人体活化的 T 细胞

• 批准号: G0800746/1
• 负责人: Thomas MacDonald
• 金额: $ 37.35万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800746%2F1
• 关键词: Inhibitory; anti; CD3; antibodies; switch

Many of the common diseases of the developed world are caused by the immune system responding to harmless molecules such as foods or plant materials, or responding to the bodies own tissues. One particular type of immune cell, called a T cell, controls these tissue-damaging responses. This proposal aims to find a way to switch off the disease causing T cells by targeting a molecule on their surface in such a way as to render the cell inactive.

发达国家的许多常见疾病是由免疫系统对无害分子（例如食物或植物材料）或对人体自身组织的反应引起的。一种特殊类型的免疫细胞（称为 T 细胞）控制着这些组织损伤反应。该提案旨在找到一种方法，通过靶向 T 细胞表面的分子，从而使细胞失活，从而关闭引起疾病的 T 细胞。