The Impact of T Cell Immunity on HIV-1 Diversity

T 细胞免疫对 HIV-1 多样性的影响

• 批准号: G108/626/1
• 负责人: Alexander Frater
• 金额: $ 115.12万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G108%2F626%2F1
• 关键词: Impact; Cell; Immunity; HIV; Diversity

Despite intensive research there is still no effective HIV vaccine. There has been a recent international call to suspend clinical vaccine trials and to concentrate on the underlying molecular biology that determines how and why a vaccine might succeed. This project aims to address these fundamental issues.HIV has the ability to adapt to its environment in a manner unprecedented in any other organism. This is reflected by the rapid development of resistance to antiviral drugs and by the development of mutations that camouflage the virus from the immune system. This project will demonstrate how, in a population of newly infected HIV positive individuals, the virus that has been transmitted will adapt to a key component of the immune system of the new host and simultaneously revert many of the mutations acquired during infection of the previous host. As patients progress to AIDS we hope to show how the immune system is no longer able to exert any selection pressure on the virus.We will explore the key components of our immune system to see whether adaptation to one may be disadvantageous to others. If so, the impact of viral evolution on the efficacy of our immune system may be more significant than realised.

尽管进行了深入研究，但仍然没有有效的HIV疫苗。最近有一个国际呼吁暂停临床疫苗试验，并专注于基础分子生物学，以决定疫苗如何以及为什么成功。该项目旨在解决这些基本问题。HIV能够以任何其他生物体前所未有的方式适应其环境。这是对抗病毒药物的耐药性的快速发展以及伪装免疫系统病毒的突变的发展所反映的。该项目将证明，在新感染的艾滋病毒阳性个体中，传播的病毒如何适应新宿主的免疫系统的关键组成部分，并同时恢复了先前宿主感染期间获得的许多突变。随着患者的发展，我们希望展示免疫系统如何不再能够对病毒施加任何选择压力。我们将探索我们的免疫系统的关键组成部分，以查看适应对某人的适应性是否不利。如果是这样，病毒进化对我们免疫系统功效的影响可能比实现的意义更重要。