Identifying the mechanism of the G2 phase UV checkpoint and repair response commonly defective in melanoma

确定黑色素瘤中常见缺陷的 G2 期 UV 检查点和修复反应的机制

• 批准号: nhmrc : 1064807
• 负责人: Dr Sandra Pavey
• 金额: $ 37.98万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-mechanism-g2-defective-melanoma/455136
• 关键词: Identifying; mechanism; G2; phase; UV

The UV component of sunlight is the major environmental factor driving the development of melanoma. UV radiation can directly mutate genes resulting in their inability to perform normal functions which may contribute to cancer. Despite the high number of mutations directly attributable to UV radiation, the mechanisms known to repair these mutations are generally normal in melanoma. This research will investigate a repair mechanism we have identified that is commonly defective in melanomas.

阳光中的紫外线成分是推动黑色素瘤发展的主要环境因素。紫外线辐射可以直接使基因突变，导致它们无法执行正常功能，这可能导致癌症。尽管直接归因于紫外线辐射的突变数量很高，但已知修复这些突变的机制在黑素瘤中通常是正常的。这项研究将探讨我们已经确定的黑色素瘤中常见缺陷的修复机制。