Erice School of Biophysics Conference on Channels and Transporters

埃里斯生物物理学院通道和转运蛋白会议

• 批准号: 7894639
• 负责人: LOUIS J DE FELICE
• 金额: $ 3.18万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7894639
• 关键词: Area; Attention; Biomedical Research; Biophysics; Cell physiology; Commit; Discipline; Disease; Drug abuse; Educational workshop; Fertilization; Gated Ion Channel; Homeostasis; Image; International; Ion Channel; Ions; Ligands; Link; London; Metabolic; Modeling; Molecular Conformation; Mutation; Neurotransmitters; Nutrient; Participant; Pharmaceutical Preparations; Pharmacologic Substance; Physiological; Postdoctoral Fellow; Property; Proteins; Regulation; Research; Research Personnel; Role; Schools; Scientist; Series; Sicily; Structure; Students; Synaptic Transmission; Time; Water; Woman; career; comparative; drug discovery; graduate student; human disease; lecturer; lectures; mathematical model; meetings; molecular dynamics; news; patch clamp; posters; programs; symposium; voltage

DESCRIPTION (provided by applicant): We request support for the third International School of Biophysics conference on "Transporters and Channels" to be held in Erice, Sicily, 12-18 May 2008. We also request a continuation meeting to be held in 2011. The 2008 meeting is a sequel to the 2002 and NIMH-supported 2005 meetings. The 2008 meeting was planned to occur just before a complementary meeting organized by Frances Ashcroft in London. Students and speakers from the Erice conference may thus continue to London. Few meetings pay exclusive attention to the relationship between transporters and channels, but focus instead on transporters or channels with little crosstalk. Numerous reviews, new research, and recent conferences like ours have changed this landscape. Nevertheless, young researchers may be unaware of career opportunities offered by a comprehensive and comparative view of transporters and channels. Channel- and transporter-related diseases, protein regulation, molecular dynamics, and drug discovery are a few examples of intersecting research areas. Thus, there is a continuing need for a meeting with lecturers and participants from both disciplines. The Erice meeting - which is modeled after Gordon Research Conferences but with emphasis on an interdisciplinary, early career audience - offers unprecedented opportunities for interactions between channel and transporter researchers for professional contacts and opportunities. Transporters and channels are crucial for virtually every cell function, including synaptic transmission, metabolic and nutrient transport, water and ion homeostasis, and excitability. The list of diseases linked to transporter and channel mutations is growing. Transporters also have current-generating conformations, but little is understood about the physiological role of the endogenous channel states in transporters or about the structural correlates of these channel states. The series of lectures we propose includes background sessions, workshops, and seminars. Leading researchers from ion channel and transporter fields have agreed to take part, and we will accept students from all fields with a view toward information exchange and cross-fertilization. The program will cover ligand- and voltage-gated ion channels, Na-coupled neurotransmitter transporters, H-coupled neurotransmitter, nutrient and drug transporters, H/Cl exchangers, K+, H+, and Ca++ channels, Cl- channels, crystal structures of channels and transporters, computational molecular dynamics, and mathematical models of transport. Workshops on patch clamp, amperometry, and fluorescent imaging are supplemental. The meeting consists of 3 plenary speakers, 20 lectures, 3 workshops, and 2 poster sessions. A late-invitation speaker is planned for breaking news. All speakers are committed to prepare their lectures for a diverse audience of graduate students, postdoctoral fellows, early career academics, and pharmaceutical researchers. Recruitment will pay attention to women and under-represented groups, and, in keeping with the Erice tradition, there will ample time for informal discussions. Transporters and channels are crucial for many cell functions including synaptic transmission, metabolic and nutrient transport, water and ion homeostasis, and excitability, and the list of diseases linked to transporter and channel mutations is growing. Transporters and channels are different yet they have many common properties; e.g., transporters have channel conformations but little is understood about the significance of these states for human diseases, drug abuse, and possible therapies. This conference includes background sessions and advanced seminars in these two fields so that leading researchers from the channel and transporter fields, as well as younger students and early career scientists, can benefit from cross-fertilization of these important research areas with potential benefit to biomedical research.

描述（由申请人提供）：我们请求支持将于2008年5月12日至18日在西西里埃里切举行的第三届国际生物物理学院会议“转运体和通道”。我们还请求在2011年举行一次续会。2008年的会议是2002年和NIMH支持的2005年会议的续集。2008年会议计划在弗朗西斯·阿什克罗夫特在伦敦组织的补充会议之前举行。学生和演讲者从厄里斯会议因此可以继续到伦敦。很少有会议专门关注传输器和通道之间的关系，而是关注传输器或串扰很小的通道。无数的评论、新的研究和最近的会议，比如我们的会议，已经改变了这一局面。然而，年轻的研究人员可能不知道运输和渠道的全面和比较的观点所提供的职业机会。通道和转运相关疾病，蛋白质调控，分子动力学和药物发现是交叉研究领域的几个例子。因此，仍然需要与来自这两个学科的讲师和与会者举行会议。埃里斯会议-这是仿照戈登研究会议，但重点是跨学科，早期的职业观众-提供了前所未有的机会，通道和运输研究人员之间的专业接触和机会的互动。转运蛋白和通道对几乎所有细胞功能都至关重要，包括突触传递、代谢和营养运输、水和离子稳态以及兴奋性。与转运蛋白和通道突变有关的疾病清单正在增加。转运蛋白也有电流产生的构象，但很少有人了解的生理作用的内源性通道状态的转运蛋白或这些通道状态的结构相关性。我们建议的系列讲座包括背景会议，讲习班和研讨会。来自离子通道和转运体领域的主要研究人员已经同意参加，我们将接受来自各个领域的学生，以促进信息交流和交叉施肥。该计划将涵盖配体和电压门控离子通道，钠耦合神经递质转运体，H耦合神经递质，营养和药物转运体，H/Cl交换器，K+，H+和Ca++通道，Cl-通道，通道和转运体的晶体结构，计算分子动力学和运输的数学模型。膜片钳，电流分析法和荧光成像的研讨会是补充。会议包括3个全体发言人，20个讲座，3个研讨会和2个海报会议。一个迟到的邀请演讲者计划为突发新闻。所有演讲者都致力于为研究生，博士后研究员，早期职业学者和制药研究人员的各种观众准备他们的讲座。征聘工作将注意妇女和代表性不足的群体，并按照埃里切的传统，将有充分的时间进行非正式讨论。转运蛋白和通道对许多细胞功能至关重要，包括突触传递、代谢和营养物质运输、水和离子稳态以及兴奋性，与转运蛋白和通道突变相关的疾病清单正在增加。转运体和通道是不同的，但它们具有许多共同的属性;例如，转运蛋白具有通道构象，但是对于这些状态对于人类疾病、药物滥用和可能的治疗的重要性知之甚少。本次会议包括这两个领域的背景会议和高级研讨会，以便来自通道和运输领域的领先研究人员以及年轻学生和早期职业科学家可以从这些重要研究领域的交叉施肥中受益，这些研究领域对生物医学研究具有潜在的益处。