Training in bacteriology

描述(由申请人提供)：我们不断壮大的微生物学家社区已经为指导原核生物生物学的博士后和博士后学员创造了一个出色的环境。这一努力现在正在培养高素质的个人，以满足与细菌学和新出现和重新出现的细菌疾病日益严重的问题有关的国家和国际优先事项。鉴于我们项目在教师和受训人员方面的增长，我们再次提交这份提案，在宾夕法尼亚大学建立一个由NIH支持的新的细菌学培训项目。该培训计划将每年支持2-3名博士后研究员和1名博士后研究员，使他们能够在由主要研究人员指导的12个实验室中的任何一个获得深入经验，这些实验室研究细菌生理学或人类、动物或植物疾病的重要方面。与这项T32提案相关的培训师之所以被选中，是因为他们在这些领域的研究计划已经建立得很好，得到了NIH或其他联邦拨款的支持，和/或在这些主题上发表了广泛的文章。原核生物社区的优势之一是多样性，这种多样性已经促进了这所领先研究型大学的三个学院和六个系之间的富有成效的科学互动。培训员小组涵盖细菌的主要研究领域，包括主要细胞外(Weiser，肺炎链球菌和流感嗜血杆菌；Binns，根癌杆菌；Yuk，波尔德氏菌；朱，霍乱弧菌；以及希弗利，大肠杆菌和鼠疫杆菌)和细胞内(Goldfine，单核细胞增生菌；内容包括：病原体(Paterson、Schifferli和Weiser)；新型疫苗的开发(Paterson、Schifferli和Weiser)；免疫致病机理和细菌在免疫治疗中的应用(Paterson、沈、Yuk)；关键成分细菌细胞表面的结构和功能(Goulian、Daldal、Pohlschroder)；以及靶细胞的细菌信号(Binns、Goulian、Yuk、朱)。这些培训者在过去八年中总共发表了关于22种细菌的文章，这些文章再加上他们实验室中可用的研究主题和技术的广度，为目前和未来的培训者提供了大量的研究机会。培训者提供的研究机会，加上强大的机构承诺和广泛而组织良好的培训计划，有望为学生和博士后研究员提供出色的细菌学培训。

DESCRIPTION (provided by applicant): Our growing community of microbiologists has developed an outstanding environment for mentoring pre- and postdoctoral trainees in prokaryotic biology. This effort is now producing highly qualified individuals to meet national and international priorities related to bacteriology and to the growing problems of emerging and re-emerging bacterial diseases. Given the growth of our program, both in terms of faculty and trainees, we resubmit this proposal to establish a new NIH-supported Training Program in Bacteriology at the University of Pennsylvania. The Training Program would support 2-3 Ph.D. candidate predoctoral fellows as well as one postdoctoral fellow per year, enabling them to obtain an in-depth experience in any one of 12 laboratories directed by principal investigators who study important aspects of bacterial physiology or diseases of humans, animals or plants. The trainers associated with this T32 proposal have been selected because their research programs in these areas are well established, being supported by NIH or other federal grants and/or having published extensively on these topics. One of the strengths of the prokaryotic community is a diversity that has already fostered productive scientific interactions between three Schools and six Departments at this leading research university. The group of trainers encompasses the major areas of research on bacteria including bacterial-host interactions of leading extracellular (Weiser, S. pneumoniae and H. influenzae; Binns, A. tumefaciens; Yuk, Bordetella spps; Zhu, V. cholerae; and Schifferli, E. coli and V. pestis) and intracellular (Goldfine, L. monocytogenes; Rubin, M. tuberculosis) pathogens, the development of novel vaccines (Paterson, Schifferli and Weiser), immunopathogenesis and use of bacteria as agents in immunotherapy (Paterson, Shen, Yuk), the structure and function of key components bacterial cell surface (Goulian, Daldal, Pohlschroder) and bacterial signaling of target cells (Binns, Goulian, Yuk, Zhu). These trainers have together published articles on over twenty-two bacterial species in the past eight years, which, in conjunction with the breadth of research topics and techniques available in their laboratories, offers numerous research opportunities for current and future trainees. The research opportunities provided by the trainers coupled with strong institutional commitment and an extensive and well-organized training program promises to provide excellent training in bacteriology to both students and postdoctoral fellows.