Developmental Biology Training Grant

描述（由申请人提供）：此申请是为了更新对发育生物学研究生培训计划的支持。在一个发育生物学研究项目中，有大约66名研究生和47名博士后实习生，需要9个博士前职位。在过去的一年里，该项目增加了三名研究小鼠发育生物学的新教员（这是该项目的一个新研究领域），还增加了三名进化/发展领域的教员培训师。这些变化为我们的核心发育生物学培训计划增加了新的优势和广度。拟议的培训计划强调在一组互动式教师中进行个性化的研究生研究培训，为每个学生提供不同的培训投入，许多学生有共同导师，允许他们整合来自两个实验室的研究培训。每个博士预科生都由一个教师委员会指导，指导学生完成一个高度个性化的培训项目；除了许多非正式会议（例如，期刊俱乐部和研究研讨会）之外，委员会每年至少召开一次会议，从而对学生的进步进行了良好的监控，并创造了一个支持性的环境。

DESCRIPTION (provided by applicant): This application is to renew support for a developmental biology graduate training program. Funds are requested for nine predoctoral positions, within a developmental biology research program that includes approximately 66 graduate students and 47 postdoctoral trainees. Over the past year the program has added three new faculty working on developmental biology of the mouse ~ a new research area for this program - as well as adding three faculty trainers in the area of evolution/development. These changes add new strengths and breadth to our core developmental biology training program. The proposed training program emphasizes individualized graduate research training within a group of interactive faculty that provides each student with diverse training input, and a number of students have co-advisors allowing them to integrate research training from two laboratories. Each predoctoral student is advised by a faculty committee that guides the student through a highly individualized training program; the committee meets at least once every year, in addition to many informal meetings (e.g., journal clubs and research seminars), resulting in excellent monitoring of the student's progress and the creation of a supportive environment. Twenty training faculty directly participate in the program. Faculty are all members in the Institute of Molecular Biology (ten), the Institute of Neuroscience (seven), or the Department of Biology (three). The University of Oregon's research Institutes provide an interactive investigative environment; they bring together laboratories with common interests, run graduate programs, provide space and funding support, and have annual retreats. Institutes also support shared research facilities - such as the Genomics and Proteomics Center, Transgenic Mouse Facility, Monoclonal Antibody Facility, and Bio-Optic Center - all staffed with expert personnel who are available to the students for training and assistance in experimental design. The Institute of Molecular Biology and Institute of Neuroscience together provide an interdisciplinary approach to developmental biology that includes computational biology, structural biology, cell biology, neuroscience, and evolutionary biology. This breadth of training combines well with the highly focused project-oriented research training the students receive in their host laboratories, producing creative scientists who will be able to develop their own first-rate research programs, thereby strengthening the national resource in developmental biology. PUBLIC HEALTH RELEVANCE: Training in Developmental Biology is essential to understand the mechanisms that go awry in many diseases, including a number of devastating birth defects such as lissencephaly. Many adult onset diseases, such as numerous cancers, appear to be due to developmental programs that are inappropriately expressed in the adult. The best way to understand, and thus design treatments, for these diseases is to train basic and clinical scientists in developmental biology.