Identifying novel targets to treat and prevent diabetic complications

确定治疗和预防糖尿病并发症的新靶点

• 批准号: nhmrc : 1059124
• 负责人: Prof Karin Jandeleit-Dahm
• 金额: $ 46.49万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-novel-targets-diabetic-complications/454733
• 关键词: Identifying; novel; targets; treat; prevent

Diabetes is the leading cause for kidney failure requiring dialysis or transplantation. Diabetic patients also have a higher risk to suffer from heart attacks, stroke and amputations in particular once kidney damage occurs. Current strategies fail to completely protect patients from complications. My research will uncover knowledge gaps in our understanding of diabetes complications, identify new targets ultimately leading to urgently needed more effective treatments and prevention strategies to reduce the burden of disease in diabetes.

糖尿病是肾衰竭的主要原因，需要透析或移植。糖尿病患者患心脏病、中风和截肢的风险也更高，特别是在肾脏受损的情况下。目前的策略未能完全保护患者免受并发症的影响。我的研究将揭示我们在了解糖尿病并发症方面的知识差距，确定新的目标，最终导致迫切需要更有效的治疗和预防战略，以减轻糖尿病疾病的负担。