Gender Differences in Growth in Pediatric Patients with Crohn's Disease

克罗恩病儿科患者生长的性别差异

• 批准号: 7806776
• 负责人: Neera Gupta
• 金额: $ 0.11万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7806776
• 关键词: Accounting; Adverse effects; Affect; Age; Applications Grants; Arts; Award; Biostatistical Methods; California; Child; Childhood; Chronic Disease; Clinic; Clinical Management; Clinical Research; Clinical Trials; Complication; Crohn' s disease; Data; Data Collection; Databases; Development; Diagnosis; Dietary intake; Disease; Endocrinologist; Enrollment; Ensure; Estrogens; Etiology; Exhibits; Failure; Family; Female; Funding; Future; Gastroenterologist; Gastroenterology; Gender; Goals; Growth; Growth and Development function; Height; Hepatic; Hypothalamic structure; Impairment; Incidence; Individual; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Institution; Insulin-Like Growth Factor I; K-Series Research Career Programs; Length; Letters; Linear Regressions; Longitudinal Studies; Measurement; Measures; Medical; Medical center; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Methods; Modeling; Multivariate Analysis; Nature; Newly Diagnosed; Normal Range; Nurse Practitioners; Outcome Measure; Parents; Pathogenesis; Patient Care; Patients; Pharmaceutical Preparations; Physiological; Pilot Projects; Principal Investigator; Procedures; Production; Prospective Studies; Protocols documentation; Quality of life; Registries; Regression Analysis; Regulation; Relative (related person); Research; Research Design; Research Infrastructure; Research Personnel; Resources; Retrospective Studies; Risk; Risk Factors; San Francisco; Serum; Severities; Severity of illness; Sex Characteristics; Site; Somatotropin; Staging; Statistical Methods; Statistical Models; Techniques; Testing; Testosterone; Texas; Time; Training Programs; Tumor Necrosis Factor-alpha; Universities; Weight; Writing; age effect; base; bone age; career; career development; cohort; cytokine; effective intervention; energy balance; experience; hormone resistance; hormone sensitivity; illness length; improved; indexing; interest; male; patient oriented; prevent; programs; psychosocial; public health relevance; skills; success; urinary

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Neera Gupta, a pediatric gastroenterologist at the University of California, San Francisco. Dr. Gupta is establishing herself as a young investigator in patient-oriented clinical research of pediatric inflammatory bowel disease (IBD). This K23 award will provide Dr. Gupta with the support necessary to accomplish the following goals: (1) to become expert at patient-oriented clinical research in pediatric IBD; (2) to conduct clinical investigations of endocrinologic aspects of growth in pediatric patients with IBD; (3) to implement advanced biostatistical methods in clinical studies; (4) to develop and maintain a relational database containing data from multiple sites; and (5) to develop an independent clinical research career. To achieve these goals, Dr. Gupta has assembled a mentoring team comprised of a primary mentor, Dr. Melvin Heyman, Director of the Training Program in Pediatric Gastroenterology at UCSF, who conducts clinical investigations in pediatric IBD, and three co-mentors: Dr. Robert Lustig, an endocrinologist who focuses on hypothalamic function and its regulation of growth and energy balance; Dr. Eric Vittinghoff, an expert in study design and current state-of-the-art biostatistical methods; and Dr. Michael Kohn, who has expertise in database development and management. Growth impairment is a well-recognized complication of Crohn's disease. Dr. Gupta's research will focus on the relative influence of gender and age at disease presentation and diagnosis on height and growth velocity z scores in newly diagnosed pediatric patients with Crohn's disease (Aim 1) and the relative effects of gender, pubertal development (Tanner stage) and disease activity on growth hormone/insulin-like growth factor I levels and height z scores in pediatric patients with Crohn's disease (Aim 2). In Aim 1, Dr. Gupta will use the existing infrastructure of the Pediatric IBD Consortium (composed of centers in 6 geographically distinct US regions) to enroll and follow 200 newly-diagnosed pediatric patients with Crohn's disease to determine the independent effects of gender and age at disease presentation and diagnosis on growth. In Aim 2, Dr. Gupta will conduct a single-center cross-sectional pilot study to generate preliminary data on the effects of gender, pubertal status, and disease severity on growth in children with Crohn's disease. Both studies will utilize advanced multivariate statistical methods. This research will form the basis for a multicenter longitudinal study in newly diagnosed childhood Crohn's disease, to be proposed in an R01 grant application before the end of the K award. Public health relevance: Improved understanding of the etiology and gender-associated differences in growth impairment in pediatric patients with Crohn's disease is critical to determine effective medical management strategies and may clarify the underlying mechanisms for gender differences in the course of this chronic disorder.

描述（由申请人提供）： 这是加利福尼亚大学旧金山分校的儿科胃肠病学家Neera Gupta博士颁发的K23奖。 Gupta博士正在建立自己的年轻研究者，从事以患者为导向的小儿炎症性肠病（IBD）的临床研究。该K23奖将为Gupta博士提供实现以下目标所需的支持：（1）成为小儿IBD的以患者为导向的临床研究的专家； （2）对小儿IBD患者的内分泌生长的内分泌方面进行临床研究； （3）在临床研究中实施先进的生物统计学方法； （4）开发和维护一个关系数据库，该数据库包含来自多个站点的数据； （5）发展独立的临床研究职业。 To achieve these goals, Dr. Gupta has assembled a mentoring team comprised of a primary mentor, Dr. Melvin Heyman, Director of the Training Program in Pediatric Gastroenterology at UCSF, who conducts clinical investigations in pediatric IBD, and three co-mentors: Dr. Robert Lustig, an endocrinologist who focuses on hypothalamic function and its regulation of growth and energy balance;研究设计和当前最新生物统计学方法的专家Eric Vittinghoff博士；迈克尔·科恩（Michael Kohn）博士，他在数据库开发和管理方面具有专业知识。 生长障碍是克罗恩病的公认并发症。 Gupta博士的研究将侧重于新诊断的克罗恩病儿科患者（AIM 1）以及性别，青春期发展（Tanner阶段）和疾病活性对生长激素/胰岛素样疗法Z SCORES（AIM i s sco s sco s co socor in ot of ot a pediatric s sco s sco s sco s sco s sco s sco s scor，gupta博士将侧重于疾病表现和诊断对疾病表现和诊断对身高和生长速度Z评分的相对影响（AIM 1）。在AIM 1中，Gupta博士将使用儿科IBD财团（由6个地理上不同地区的中心组成）的现有基础设施来招募并遵循200名新诊断的克罗恩病儿科患者，以确定性别和年龄对疾病表现和诊断生长的独立影响。在AIM 2中，Gupta博士将进行一项单中心横断面试验研究，以生成有关性别，青春期状态和疾病严重程度对克罗恩病儿童生长的影响的初步数据。两项研究都将利用高级多元统计方法。这项研究将构成新诊断为儿童疾病的多中心纵向研究的基础，该研究将在k奖结束之前在R01赠款申请中提出。 公共卫生相关性：对病因学和性别相关的儿科患者的病因和性别相关差异的了解对确定有效的医疗管理策略至关重要，并且可以阐明这种慢性疾病过程中性别差异的基本机制至关重要。