RACIAL DIFFERENCES IN CIRCULATING SEX STEROIDS: MECHANISMS AND EFFECT ON BONE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的总体假设是，性类固醇水平升高可能是非洲裔美国女性一生中出现的一些与骨质疏松相关的疾病的原因，包括平滑肌瘤、内分泌相关的癌症和对骨质疏松的保护。 如果是这样，它可能开始被理解的贡献，这些过程中，保护和添加剂，在黑人女性，也将允许差异性类固醇水平在正常的月经周期，以及确定机制。 这项研究将进一步提出检查性类固醇对终末器官的影响，在这种情况下，骨矿物质密度和结构。 这项研究的目的是看看女性与白色女性相比的水平。 如果是这样，我们可能开始了解他们对黑人女性某些疾病的贡献，使我们能够改进预防这些疾病的方法。 该研究将测量正常月经周期中激素水平的差异，并确定这些差异的原因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall hypothesis of this study is that elevated sex steroid levels may account for some of the hormone-related conditions that follow throughout life in African-American females, including leiomyomas, endocrine related cancers, and protection from osteoporosis. If so, it may begin to be understood the contribution to these processes, both protective and additive, in Black females, and also will allow differences in sex steroid levels in the normal menstrual cycle, as well as to identify mechanisms. The study will further propose to examine the effects of sex steroids on an end organ-in this case bone mineral density and architecture. The purpose of this study is to see if levels of female compared to white females. If so, we may begin to understand their contribution to certain illnesses in Black females allowing us to improve methods of preventing medical these illnesses. The study will measure differences in hormone levels in the normal menstrual cycle, as well as determine reasons for these differences.