Building Core Programs in Cardiovascular and Metabolic Disease

描述(由申请人提供)：本提案的目标是扩大和加强新墨西哥大学健康科学中心心血管和代谢性疾病签名研究计划(CVMD)内的一个核心中心。核心是血管生物学研究和培训核心，其主题重点是全身和肺高压的机制，以及与代谢性疾病相关的血管病理。这项申请的短期目标是聘请一名有针对性的新独立调查员(NIL)来扩大核心的研究能力，并提供必要的资源来促进该个人的学术研究事业。已确定的零是一位杰出的年轻少数族裔候选人。Nikki Jernigan博士将为核心带来新的研究方向和技术方法，他将在核心内部促进未来的多学科研究资金，并促进在联东综合团创造就业机会。这一应用的长期目标是发展一个国内和国际公认的、多学科的研究卓越中心，旨在了解心血管疾病的发病机制，并改进和开发新的治疗方式。为了实现这些目标，为核心的主题、科学和基础设施组织提出了以下具体目标：(1)P30赠款将提供机会，增加关键的新教员，以加强研究慢性持续和间歇性低氧引起的肺动脉高压、系统性高血压和糖尿病相关血管功能障碍的机制的合作和多学科研究团队。(2)P30将立即提供资源，支持针对这一目标教师候选人的试点项目。此外，核心还将提供独特的研究专业知识、共享的设备和设施、财务研究和工资支持以及智力资源，以支持这名新员工的职业发展。(3)将建立一个核心实验室设施，其中包括高分辨率共聚焦显微镜、电生理学和遥测系统的基本设备，用于监测心血管疾病动物模型的血流动力学变化的发展。这一设施将针对北港岛线的具体需要而开发，将补充现有的共享资源，并将进一步加强多学科核心的研究基础设施。(4)将为NIL制定一项指导计划，其中包括一个由心血管和肺生理学、电生理学、血管生成以及G蛋白受体功能和信号领域的知名、有资金支持的研究人员组成的咨询委员会。该指导计划的基本目标是确保符合计划报告要求，促进近距离研究与核心的其他研究人员之间的合作研究努力，并跟踪和评估近距离研究的进展，包括开发R01应用程序，以确保候选人作为一名能够加强核心的使命和愿景的多产和独立的研究人员继续取得成功。 心血管疾病是美国主要的死亡原因。同样，糖尿病和肥胖症是美国和新墨西哥州的主要健康问题。这些情况密切相关，糖尿病和肥胖会增加心血管疾病、高血压、肾脏疾病和失明的风险。这项提议的目的是扩大和加强新墨西哥大学HSC的一个核心中心，该中心的任务是确定导致这些疾病发展的因素，这些因素将导致新的预防和治疗战略。

DESCRIPTION (provided by applicant): The goal of this proposal is to expand and strengthen a Core center within the Cardiovascular and Metabolic Disease Signature Research Program (CVMD) at the University of New Mexico Health Sciences Center (UNMHSC). The Core is the Vascular Biology Research and Training Core, which has a thematic focus on the mechanisms of systemic and pulmonary hypertension, and metabolic disease-related vascular pathology. The short term goal of this application is to hire a targeted newly-independent investigator (NIl) to expand the research capacity of the Core and provide the resources needed to promote the academic research career of this individual. The identified NIl is an outstanding young minority candidate. Dr. Nikki Jernigan, who will bring new research directions and technical approaches to the Core, will catalyze future multidisciplinary research funding within the core and promote job creation at the UNMHSC. The long term goal of this application is to develop a nationally and internationally recognized, multidisciplinary center of research excellence aimed at understanding the pathogenesis of cardiovascular diseases and to improve and develop new therapeutic modalities. To achieve these objectives, the following specific aims are proposed for the thematic, scientific and infrastructural organization of the Core: (1) The P30 grant will provide the opportunity to add a critical new faculty hire to enhance a collaborative and multidisciplinary team of researchers studying mechanisms of chronic sustained and intermittent hypoxia induced pulmonary hypertension, systemic hypertension, and diabetes-related vascular dysfunction. (2) The P30 will provide immediate resources to support a pilot project for this targeted faculty candidate. The Core will additionally provide unique research expertise, shared equipment and facilities, financial research and salary support, and intellectual resources to support the career development of this new hire. (3) A Core Laboratory Facility will be created that includes essential equipment for high resolution confocal microscopy, electrophysiology, and telemetry systems for monitoring the development of hemodynamic changes in animal models of cardiovascular disease. This facility will be developed to target the specific needs of the NIl, will complement existing shared resources, and will further enhance the research infrastructure of the multidisciplinary core. (4) A mentoring program will be developed for the NIl that includes an advisory committee of established, funded investigators in the areas of cardiovascular and pulmonary physiology, electrophysiology, angiogenesis, and G protein receptor function and signaling. Essential goals of this mentoring program are to assure compliance with program reporting requirements, to promote collaborative research efforts between the NIl and other investigators of the Core, and to track and assess the progress of the Nil, including the development of an R01 application to ensure the continued success of the candidate as a productive and independent investigator who can enhance the mission and vision of the Core. Cardiovascular diseases are the leading cause of death in the U.S. Likewise, diabetes and obesity are major health problems in the U.S. and in New Mexico. These conditions are tightly related such that diabetes and obesity increase the risk of cardiovascular disease, high blood pressure, kidney disease and blindness. The aim of this proposal is to expand and strengthen a Core center at the University of New Mexico HSC, the mission of which is to identify factors responsible for the development of these diseases that will lead to new prevention and treatment strategies.