Baylor's Program for Bioengineering Sciences and Translational Research "B-BEST"

描述（由申请人提供）：这个拟议的项目，题为“贝勒的生物工程科学和转化研究计划（B-BEST）”，将提供两个新的教师在生物工程科学和转化研究的专业知识的招聘和发展的支持。这些首次任教的教师将增加组织再生领域的专业知识，以弥合基础和临床研究之间的差距。他们的技能将补充和增加BCD的生物医学科学（BMS），其教师从事临床相关的，跨学科性质的转化研究部门的现有优势。P30支持的初级教师将通过增加他们对导致颅面组织正常和异常发育/结构/功能的潜在生物学机制的了解来发展自己的组织再生研究。通过借鉴BMS内部强大的指导基础设施，P-30支持的教师将在两个部门中交叉任命。该研究所与德州大学阿灵顿分校的牙周病学或口腔颌面外科学系以及生物工程/生物医学工程研究生课程系合作，以促进矿化和软组织再生领域的多学科生物工程应用。BMS和BCD的基础，翻译和临床研究人员网络将协助P-30教师推动仿生和/或纳米结构支架，干细胞使用和生物活性因子/药物递送的新技术。此类方法将为未来的独立研究项目赠款提供框架，从而进一步推进BMS/BCD的使命。该项目的长期目标如下：1）通过招聘和保留额外的优秀教师，改善研究资源，扩大研究合作，加强研究能力在BCD; 2）提供额外的重点，方向，并在BMS/BCD的研究计划在跨越基础，转化和临床研究频谱的领域取得成功的结果; 3)增加与UTA，SMU和UTSW现有生物医学工程研究小组在牙科和颅面健康领域合作的机会;和4）为对生物工程和转化研究感兴趣的博士前牙科学员提供培训机会。 公共卫生相关性：这项研究补助金将提供资金，用于聘请两名第一次在组织再生部门的专业知识的教员。贝勒牙科学院的生物医学科学教授这些教师将与目前从事颅面组织基础和转化研究的教师合作。组织再生研究的进展将带来对各种颅面疾病的治疗，这些疾病困扰着许多人。

DESCRIPTION (provided by applicant): This proposed project, entitled "Baylor's Program in Bioengineering Sciences and Translational Research (B-BEST)", will provide support for the hiring and development of two new faculty with expertise in Bioengineering Sciences and Translational Research. These first-time faculty will add expertise in the area of Tissue Regeneration needed to bridge the gap between basic and clinical research. Their skills will complement and add to existing strengths of BCD's Department of Biomedical Sciences (BMS), whose faculty engage in clinically-relevant, translational research that is interdisciplinary in nature. The P30-supported junior faculty will develop their own studies in tissue regeneration by increasing their knowledge of the underlying biological mechanisms leading to the normal and abnormal development/structure/function of craniofacial tissues. By drawing from the strong infrastructure for mentorship within BMS, the P-30-supported faculty will be cross-appointed in either the Depts. of Periodontics or Oral and Maxillofacial Surgery, and the Department of Bioengineering/Biomedical Engineering Graduate Program at UT-Arlington to foster multi-disciplinary bioengineering applications in the area of mineralized and soft tissue regeneration. The network of established basic, translational and clinical researchers in BMS and BCD will assist P-30 faculty in driving new technologies for biomimetic and/or nanostructured scaffolds, use of stem cells, and the delivery of bioactive factors/drugs. Such approaches will provide the framework for future independent research project grants that will further the mission of BMS/BCD. The long-term aims of this project are the following: 1) Strengthen research capacity through recruitment and retention of additional outstanding faculty, improved research resources, and expanded research collaborations at BCD; 2) Provide additional focus, directions, and successful outcomes to the research programs in BMS/BCD in areas spanning the basic, translational, and clinical research spectrum.; 3) Increase opportunities to collaborate with existing biomedical engineering research groups at UTA, SMU, and UTSW in the area of dental and craniofacial health; and 4) Provide training opportunities for predoctoral dental trainees interested in bioengineering and translational research. PUBLIC HEALTH RELEVANCE: This research grant will provide funding for the hiring of two first-time faculty members with expertise in tissue regeneration in the Dept. of Biomedical Sciences at Baylor College of Dentistry. These faculty will work with the present faculty who perform basic and translational research on craniofacial tissues. Advances in tissue regeneration research will bring about treatments for various kinds of craniofacial maladies that afflict many in the population.