SPORE Leukemia Tissue Bank
SPORE白血病组织库
基本信息
- 批准号:7715181
- 负责人:
- 金额:$ 11.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2014-06-30
- 项目状态:已结题
- 来源:
- 关键词:Acute Lymphocytic LeukemiaAcute Myelocytic LeukemiaAnimal ModelArtsBasic ScienceBiologicalBiologyBiometryBloodBone MarrowCancer and Leukemia Group BCell LineCellsChronic Lymphocytic LeukemiaChronic Myeloid LeukemiaClinicalClinical DataClinical ProtocolsCollectionCommitCorrelative StudyDNADatabasesDysmyelopoietic SyndromesEnrollmentFundingGoalsHematologic NeoplasmsIndividualInstructionInvestigationJournalsLaboratoriesLaboratory FindingLeadershipMapsMolecularNational Cancer InstituteNormal tissue morphologyOhioOutcomePathologicPathologyPatientsPeer ReviewProcessPropertyProteinsPublishingRNAReproduction sporesResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResearch SupportResourcesRoleSamplingSpecimenStructureTherapeuticTissue BankingTissue BanksTissue ProcurementsTissue SampleTissuesTranslatingTreatment ProtocolsUniversitiesValidationVertebral columnWorkbasebiomedical informaticsdata sharingexperiencehuman diseasehuman tissueinterestleukemialeukemia tissue bankpopulation basedrepositorysuccesstool
项目摘要
On order to successfully translate basic research in leukemia to the clinical setting, as well as to better
understand the relevance of observed clinical or population-based phenomena through laboratory-based
research, an extensive repository of tissue samples, with accompanying pathologic and clinical data, procured
from leukemia patients is necessary. To fulfill this role. Core A will provide researchers in the Leukemia SPORE
access to a relatively unprecedented repository of uniformly prepared and fully characterized leukemia patient
samples. The already well-established Ohio State University and CALGB Leukemia Tissue Banks (referred to
as SPORE LTBs) constitute the backbone of Core A, and contribute crucial experience and infrastructure to this
effort. The SPORE LTBs serves as centralized tissue banks of blood and bone marrow specimens, as well as
non-leukemic material, procured from leukemia patients enrolled on CALGB or OSU treatment protocols, and
provide these to investigators within and outside of OSU. This work will integrate with Cores B (biostatistics) and
C (Biomedical informatics) to maintain a detailed, current database of samples and accompanying clinical
information available. Beyond simply serving as a cell repository. Core A will perform regular validation of
sample quality, conduct molecular characterizations, and prepare derivatives (protein, DNA, RNA). The
availability of this infrastructure for procuring samples, and the large number of samples already in our
possession, will greatly facilitate the conduct of the research projects of this SPORE proposal as well as provide
an important and widely available resource for extended studies by investigators within this or outside the OSU
Leukemia SPORE. The specific aims of Core A are: (1) To provide central collection, processing and a state-of-
the-art repository for samples collected from leukemia patients treated on clinical protocols that are relevant to
the OSU Leukemia SPORE; (2) To provide materials from processed clinical samples to interested
investigators, within and outside of the OSU Leukemia SPORE, who examine relevant cellular and molecular
properties of leukemia and correlate these properties with clinical or population-based outcomes and who
commit to sharing the data derived from their research efforts. The effective collection and characterization of
leukemia samples by Core A and their provision to SPORE investigators is critical to the success of the research
proposed. The infrastructure of this Core A is therefore already in place, and partially supported through NCI
funding through both the CALGB and OSUCCC, In this Core proposal, we seek supplemental and not
overlapping funding for support ofthe SPORE projects
RELEVANCE (See instructions):
Biological mechanistic investigations rely on cell lines or animal models. While these are powerful research
tools, validating laboratory findings in human tissue is crucial to understand their relevance to human
disease. This Core will provide SPORE researchers with simplified access to a large repository of leukemia
patient samples and accompanying clinical information. This multi-tiered effort is essential to the overall goal
of this SPORE group to bring their findings to the practical benefit of patients with leukemia.
为了成功地将白血病的基础研究转化为临床环境,以及更好地
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('GUIDO MARCUCCI', 18)}}的其他基金
The Role of miR-142 in the Transformation of Clonal Hematopoietic Disorders into AML
miR-142 在克隆性造血障碍转化为 AML 中的作用
- 批准号:
10367856 - 财政年份:2022
- 资助金额:
$ 11.47万 - 项目类别:
The Role of miR-142 in the Transformation of Clonal Hematopoietic Disorders into AML
miR-142 在克隆性造血障碍转化为 AML 中的作用
- 批准号:
10544734 - 财政年份:2022
- 资助金额:
$ 11.47万 - 项目类别:
Vascular Remodeling in the Bone Marrow Leukemic Niche: A Therapeutic Target?
骨髓白血病微环境中的血管重塑:治疗目标?
- 批准号:
10371023 - 财政年份:2020
- 资助金额:
$ 11.47万 - 项目类别:
Vascular Remodeling in the Bone Marrow Leukemic Niche: A Therapeutic Target?
骨髓白血病微环境中的血管重塑:治疗目标?
- 批准号:
10094210 - 财政年份:2020
- 资助金额:
$ 11.47万 - 项目类别:
Vascular Remodeling in the Bone Marrow Leukemic Niche: A Therapeutic Target?
骨髓白血病微环境中的血管重塑:治疗目标?
- 批准号:
10600088 - 财政年份:2020
- 资助金额:
$ 11.47万 - 项目类别:
Validation of microRNAs as therapeutic targets in hematological malignancies
验证 microRNA 作为血液恶性肿瘤治疗靶点
- 批准号:
8815267 - 财政年份:2011
- 资助金额:
$ 11.47万 - 项目类别:
Validation of microRNAs as therapeutic targets in hematological malignancies
验证 microRNA 作为血液恶性肿瘤治疗靶点
- 批准号:
8627134 - 财政年份:2011
- 资助金额:
$ 11.47万 - 项目类别:
Molecular characterization of normal cytogenetics AML in older patients
老年患者正常细胞遗传学 AML 的分子特征
- 批准号:
7471096 - 财政年份:2008
- 资助金额:
$ 11.47万 - 项目类别:
Molecular characterization of normal cytogenetics AML in older patients
老年患者正常细胞遗传学 AML 的分子特征
- 批准号:
7614313 - 财政年份:2008
- 资助金额:
$ 11.47万 - 项目类别:
Pharmacologic modulation of chromatin remodeling in leu*
leu* 染色质重塑的药理学调节
- 批准号:
7096021 - 财政年份:2005
- 资助金额:
$ 11.47万 - 项目类别:
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