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EFALIZUMAB (RAPTIVA) COMBINED WITH SIROLIMUS IN TYPE 1 DIABETIC ISLET ALLOGRAFT

EFALIZUMAB (RAPTIVA) COMBINED WITH SIROLIMUS IN TYPE 1 DIABETIC ISLET ALLOGRAFT
EFALIZUMAB (RAPTIVA) 与西罗莫司联合用于 1 型糖尿病胰岛同种移植术
批准号：
7951730
负责人：
Bernhard Josef Hering
金额：
$1.35万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-12-01 至 2009-11-30
来源：
https://reporter.nih.gov/project-details/7951730
关键词：
AntibodiesAntithymoglobulinCell Adhesion MoleculesClinical ResearchComputer Retrieval of Information on Scientific Projects DatabaseFundingGrantImmunosuppressive AgentsInstitutionInsulin-Dependent Diabetes MellitusIslets of Langerhans TransplantationMaintenanceRaptivaResearchResearch PersonnelResourcesSirolimusSourceTreatment ProtocolsUnited States National Institutes of Healthefalizumabimprovedislet allograftnoveltype I diabetic

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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project aims to improve the applicability of islet transplantation for treatment of type 1 diabetes by utilizing novel immunosuppressive regimens centered on the use of adhesion molecule blockade with an anti-LFA-1 antibody and sirolimus maintenance with Anti-Thymocyte globulin induction.
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