EFFECTS OF THYMECTOMY DURING CARDIOTHORACIC SURGERY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标 我们计划描述由于儿童时期的心胸手术而导致的淋巴细胞群的变化。具体地说，我们计划衡量： 在过去接受过心胸手术的患者中，胸腺组织是否存在(对于正在接受手术或接受过胸部MRI或CT扫描的患者)。 儿童时期的心胸外科手术后感染的频率或类型是否发生了变化。 出现自身免疫性疾病的症状，并测量与自身免疫问题有关的特定T细胞的产生。 T细胞生成率、T细胞功能(体外)、淋巴细胞和T细胞亚群数量、常见病毒疾病的抗体和血液样本中的疫苗。 免疫前后对甲型肝炎疫苗的免疫应答(T细胞体外功能和抗体)。 婴幼儿心胸外科手术前后上述参数的变化规律

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS We plan to describe changes in lymphocyte populations which occur as a result of cardiothoracic surgery in childhood. Specifically we plan to measure: ¿ Whether thymus tissue is present or absent in individuals who have had cardiothoracic surgery in the past (for individuals who are having surgery or have had MRI or CT scans of the chest). ¿ Whether individuals have a change in frequency or type of infections after cardiothoracic surgery in childhood. ¿ Presence of symptoms of autoimmune disease and measure production of specific T cells which are related to autoimmune problems. ¿ Rate of T cell production, T cell function (in vitro), lymphocyte and T cell subset number, and antibodies to common viral illnesses and vaccines from blood samples. ¿ Response (T cell function in vitro and antibodies) to Hepatitis A vaccine before and after immunization. ¿ The above parameters in young children both before and then after cardiothoracic surgery so that we may follow the timing of the changes