EFFECTS OF THYMECTOMY DURING CARDIOTHORACIC SURGERY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标 我们计划描述的变化，淋巴细胞群体发生的结果，在儿童心胸外科手术。 具体而言，我们计划衡量： ¿ 胸腺组织是否存在或不存在于过去曾做过心胸手术的个体中（对于正在做手术或做过胸部MRI或CT扫描的个体）。 ¿ 儿童期心胸外科手术后感染的频率或类型是否发生变化。 ¿ 自身免疫性疾病症状的存在和测量与自身免疫性问题相关的特定T细胞的产生。 ¿ T细胞产生率、T细胞功能（体外）、淋巴细胞和T细胞亚群数量以及血液样本中常见病毒疾病和疫苗的抗体。 ¿ 免疫前后对甲型肝炎疫苗的应答（体外T细胞功能和抗体）。 ¿ 以上参数在幼儿心胸手术前后都有变化，这样我们就有可能跟随手术时间的变化

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS We plan to describe changes in lymphocyte populations which occur as a result of cardiothoracic surgery in childhood. Specifically we plan to measure: ¿ Whether thymus tissue is present or absent in individuals who have had cardiothoracic surgery in the past (for individuals who are having surgery or have had MRI or CT scans of the chest). ¿ Whether individuals have a change in frequency or type of infections after cardiothoracic surgery in childhood. ¿ Presence of symptoms of autoimmune disease and measure production of specific T cells which are related to autoimmune problems. ¿ Rate of T cell production, T cell function (in vitro), lymphocyte and T cell subset number, and antibodies to common viral illnesses and vaccines from blood samples. ¿ Response (T cell function in vitro and antibodies) to Hepatitis A vaccine before and after immunization. ¿ The above parameters in young children both before and then after cardiothoracic surgery so that we may follow the timing of the changes