N-METHYL-D-ASPARTATE (NMDA) RECEPTOR IN ALZHEIMER'S DISEASE

阿尔茨海默病中的 N-甲基-D-天冬氨酸 (NMDA) 受体

• 批准号: 7950816
• 负责人: ANAT BIEGON
• 金额: $ 0.55万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950816
• 关键词: Alzheimer' s Disease; Aspartate; Binding; Blood Circulation; Boxing; Brain; Brain scan; Chemicals; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Human; Image; Institution; Learning; Link; Measures; Memory; Movement; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; Neurotransmitters; New York; Positron-Emission Tomography; Protocols documentation; Radioactive; Research; Research Personnel; Resources; Role; Scanning; Source; Tail; United States National Institutes of Health; Universities; aspartate receptor; radiotracer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine whether the. radiotracer tailed (C]CNS5161 can be used to measure levels of N-methyl-D-aspartate (NMDA) receptors in the normal human brain and to see if these measures give us similar results each tithe. Tice ability to measure the level of NMDA receptors in the human brain will be important in understanding their role" in Alzheimer's Disease (AD). NMDA is a neurotransmitter in the brain that is linked with learning and memory, To image these NMDA receptors;we will use Positron Emission Tomography (PET) and a radiotracer balled (1C]CN55161. This radiotracer was developed to bind (stick) to NMDA receptors. PET is a special camera that takes pictures of the movement of a radiotracer in the body. This radiotracer is a radioactive chemical that is injected into the bloodstream in very small amounts and serves to indicate levels of NMDA receptors. You will receive three Positron Emission Tomography (PET) scans with the same radiotracer. Two of the scans will be done to image your brain. If you choose to go on memantirie therapy under a different protocol at New York University ((NYU), you will return for a third brain scan which is described on the next page in the boxed section.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是确定是否。放射性示踪剂拖尾(C)CNS5161可以用来测量正常人脑中N-甲基-D-天冬氨酸(NMDA)受体的水平，并看看这些测量是否每次都能得到类似的结果。测量人脑中NMDA受体水平的能力将对了解它们在阿尔茨海默病(AD)中的作用至关重要。NMDA是大脑中的一种神经递质，与学习和记忆有关，为了对这些NMDA受体进行成像，我们将使用正电子发射断层扫描(PET)和一种放射性示踪剂球状(1C)CN55161。这种放射性示踪剂是为了与NMDA受体结合(粘连)而开发的。宠物是一种特殊的相机，可以拍摄放射性示踪剂在体内的运动情况。这种放射性示踪剂是一种放射性化学物质，可以极少量地注射到血流中，用于指示NMDA受体的水平。您将使用相同的放射性示踪剂接受三次正电子发射断层扫描(PET)。其中两次扫描将对你的大脑进行成像。如果你选择在纽约大学((NYU))接受另一种方案的记忆疗法，你将回来进行第三次脑部扫描，这将在下一页的方框部分描述。