SACRCOIDOSIS: BIOMARKER AND ACTIVITY
SACRCOIDOSIS: BIOMARKER AND ACTIVITY
批准号:
7951987
负责人:
Henry Yeager
金额:
$0.86万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-04-01 至 2010-03-31
关键词:
Biological MarkersBronchoalveolar Lavage FluidCCL2 geneClinicalClinical ResearchComputer Retrieval of Information on Scientific Projects DatabaseDiseaseFundingGrantInstitutionInterleukin-12MuramidaseNeopterinPilot ProjectsProteomicsQuality of lifeResearchResearch PersonnelResourcesSamplingSarcoidosisSerumSigns and SymptomsSourceTumor Necrosis Factor-alphaUnited States National Institutes of HealthUrinehuman TNF proteinindexing
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
这是一项初步研究,旨在确定血清(肿瘤坏死因子-α、单核细胞趋化蛋白-1、白介素12、白介素2R、溶菌酶、新喋呤)、尿液(新喋呤)和支气管肺泡灌洗液(如果可用)中的生物标志物与活动性结节病的标准临床指标(体征、症状、PFT、X光、结节病健康相关生活质量)的相关性。样本也将被保存,以供蛋白质组学研究。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This is a pilot study to determine how well biomarkers in serum (TNF-alpha, MCP-1, IL-12, sIL-2R, lysozyme, neopterin), urine (neopterin), and bronchoalveolar lavage fluid, when available, correlate with standard clinical indices of active sarcoid disease (signs, symptoms, PFT's, x-rays, sarcoidosis health-related QOL). Samples will also be saved for proteomic studies.
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SACRCOIDOSIS: BIOMARKER AND ACTIVITY
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资助金额:$8.91万
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资助金额:$18.91万
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负责人:Henry Yeager
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依托单位:
海外基金