KATP CHANNEL

KATP频道

• 批准号: 7953803
• 负责人: Joseph Bryan
• 金额: $ 0.87万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953803
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Couples; Electron Microscopy; Funding; Goals; Grant; Institution; Insulin; Membrane; Metabolic; Metabolic Diseases; Molecular Conformation; Mutation; Non-Insulin-Dependent Diabetes Mellitus; Persistent Hyperinsulinemia Hypoglycemia of Infancy; Research; Research Personnel; Resolution; Resources; Source; Structure; Structure of beta Cell of islet; United States National Institutes of Health; glucose metabolism; macromolecule; neonatal diabetes mellitus; sensor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary goal of the project is to obtain intermediate resolution structures of the open and closed conformations of the KATP channel. The KATP channel is a metabolic sensor that couples changes in glucose metabolism to membrane electrical activity. In the pancreatic beta cell, KATP dependent membrane depolarization leads to downstream insulin release. Mutations in the channel have been implicated in a wide range of metabolic disorders including neonatal diabetes, type 2 diabetes, and persistent hyperinsulinemia hypoglycemia of infancy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的主要目标是获得 KATP 通道开放和闭合构象的中间分辨率结构。 KATP 通道是一种代谢传感器，可将葡萄糖代谢的变化与膜电活动耦合起来。在胰腺 β 细胞中，KATP 依赖性膜去极化导致下游胰岛素释放。该通道的突变与多种代谢紊乱有关，包括新生儿糖尿病、2 型糖尿病和婴儿期持续性高胰岛素血症低血糖。