KATP CHANNEL

KATP频道

• 批准号: 7953803
• 负责人: Joseph Bryan
• 金额: $ 0.87万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953803
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Couples; Electron Microscopy; Funding; Goals; Grant; Institution; Insulin; Membrane; Metabolic; Metabolic Diseases; Molecular Conformation; Mutation; Non-Insulin-Dependent Diabetes Mellitus; Persistent Hyperinsulinemia Hypoglycemia of Infancy; Research; Research Personnel; Resolution; Resources; Source; Structure; Structure of beta Cell of islet; United States National Institutes of Health; glucose metabolism; macromolecule; neonatal diabetes mellitus; sensor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary goal of the project is to obtain intermediate resolution structures of the open and closed conformations of the KATP channel. The KATP channel is a metabolic sensor that couples changes in glucose metabolism to membrane electrical activity. In the pancreatic beta cell, KATP dependent membrane depolarization leads to downstream insulin release. Mutations in the channel have been implicated in a wide range of metabolic disorders including neonatal diabetes, type 2 diabetes, and persistent hyperinsulinemia hypoglycemia of infancy.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的主要目标是获得KATP通道的开放和闭合构象的中间分辨率结构。 KATP通道是将葡萄糖代谢的变化与膜电活动偶联的代谢传感器。在胰腺β细胞中，KATP依赖性膜去极化导致下游胰岛素释放。该通道的突变与多种代谢紊乱有关，包括新生儿糖尿病、2型糖尿病和婴儿期持续性高胰岛素血症低血糖。