KATP CHANNEL
KATP频道
基本信息
- 批准号:7953803
- 负责人:
- 金额:$ 0.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-12-01 至 2009-11-30
- 项目状态:已结题
- 来源:
- 关键词:Computer Retrieval of Information on Scientific Projects DatabaseCouplesElectron MicroscopyFundingGoalsGrantInstitutionInsulinMembraneMetabolicMetabolic DiseasesMolecular ConformationMutationNon-Insulin-Dependent Diabetes MellitusPersistent Hyperinsulinemia Hypoglycemia of InfancyResearchResearch PersonnelResolutionResourcesSourceStructureStructure of beta Cell of isletUnited States National Institutes of Healthglucose metabolismmacromoleculeneonatal diabetes mellitussensor
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Primary goal of the project is to obtain intermediate resolution structures of the open and closed conformations of the KATP channel.
The KATP channel is a metabolic sensor that couples changes in glucose metabolism to membrane electrical activity. In the pancreatic beta cell, KATP dependent membrane depolarization leads to downstream insulin release. Mutations in the channel have been implicated in a wide range of metabolic disorders including neonatal diabetes, type 2 diabetes, and persistent hyperinsulinemia hypoglycemia of infancy.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
该项目的主要目标是获得KATP通道的开放和闭合构象的中间分辨率结构。
KATP通道是将葡萄糖代谢的变化与膜电活动偶联的代谢传感器。在胰腺β细胞中,KATP依赖性膜去极化导致下游胰岛素释放。该通道的突变与多种代谢紊乱有关,包括新生儿糖尿病、2型糖尿病和婴儿期持续性高胰岛素血症低血糖。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Joseph Bryan其他文献
Joseph Bryan的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Joseph Bryan', 18)}}的其他基金
Challenging the Dominant Model for ATP Regulation of KATP Channels
挑战 KATP 通道 ATP 调节的主导模型
- 批准号:
8994733 - 财政年份:2014
- 资助金额:
$ 0.87万 - 项目类别:
Challenging the Dominant Model for ATP Regulation of KATP Channels
挑战 KATP 通道 ATP 调节的主导模型
- 批准号:
8788349 - 财政年份:2014
- 资助金额:
$ 0.87万 - 项目类别:
Challenging the dominant model for ATP regulation of KATP channels
挑战 KATP 通道 ATP 调节的主导模型
- 批准号:
8630333 - 财政年份:2014
- 资助金额:
$ 0.87万 - 项目类别:
Challenging the Dominant Model for ATP Regulation of KATP Channels
挑战 KATP 通道 ATP 调节的主导模型
- 批准号:
9199412 - 财政年份:2014
- 资助金额:
$ 0.87万 - 项目类别:
TRANSGENIC MOUSE MODEL FOR FAMILIAL HYPERINSULINISM
家族性高胰岛素血症转基因小鼠模型
- 批准号:
6381037 - 财政年份:1998
- 资助金额:
$ 0.87万 - 项目类别:
TRANSGENIC MOUSE MODEL FOR FAMILIAL HYPERINSULINISM
家族性高胰岛素血症转基因小鼠模型
- 批准号:
2905823 - 财政年份:1998
- 资助金额:
$ 0.87万 - 项目类别:
TRANSGENIC MOUSE MODEL FOR FAMILIAL HYPERINSULINISM
家族性高胰岛素血症转基因小鼠模型
- 批准号:
6358711 - 财政年份:1998
- 资助金额:
$ 0.87万 - 项目类别:
TRANSGENIC MOUSE MODEL FOR FAMILIAL HYPERINSULINISM
家族性高胰岛素血症转基因小鼠模型
- 批准号:
6177496 - 财政年份:1998
- 资助金额:
$ 0.87万 - 项目类别:
相似海外基金
The costs and benefits of an empty nest: A longitudinal study of couples' relationship functioning when children leave the home
空巢的成本和收益:对孩子离开家时夫妻关系运作的纵向研究
- 批准号:
2336235 - 财政年份:2024
- 资助金额:
$ 0.87万 - 项目类别:
Continuing Grant
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk
Nuestro Sueno:夫妻干预措施的文化适应,以改善拉丁裔夫妇的 PAP 依从性和睡眠健康,对阿尔茨海默病风险产生影响
- 批准号:
10766947 - 财政年份:2023
- 资助金额:
$ 0.87万 - 项目类别:
Couples Advancing Together for Safer Conception (CAT-SC): A couples’-based intervention to improve engagement in sexual and reproductive health services for mobile fisherfolk in Kenya
夫妻共同推进安全受孕 (CAT-SC):基于夫妻的干预措施,旨在提高肯尼亚流动渔民对性健康和生殖健康服务的参与度
- 批准号:
10618411 - 财政年份:2023
- 资助金额:
$ 0.87万 - 项目类别:
Couples Motivational Interviewing to reduce drug use and HIV risk in vulnerable male couples
夫妻动机访谈,以减少弱势男性夫妇的吸毒和艾滋病毒风险
- 批准号:
10757544 - 财政年份:2023
- 资助金额:
$ 0.87万 - 项目类别:
Metabolism and Epigenetic Regulation are Couples in Transdifferentiation and Vascular Regeneration
代谢和表观遗传调控是转分化和血管再生的结合体
- 批准号:
10905167 - 财政年份:2023
- 资助金额:
$ 0.87万 - 项目类别:
Work-life balance in the with/post COVID-19 era: Mental health among dual-earner couples with pre-school child(ren)
COVID-19 时代/后时代的工作与生活平衡:有学龄前儿童的双职工夫妇的心理健康
- 批准号:
23H01042 - 财政年份:2023
- 资助金额:
$ 0.87万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Parenthood, Behaviours in Paid and Unpaid Work, and Well-being among dual earner couples in the UK
英国双职工夫妇的为人父母、有偿和无偿工作行为以及幸福感
- 批准号:
2886089 - 财政年份:2023
- 资助金额:
$ 0.87万 - 项目类别:
Studentship
Adapting an evidenced-based intervention to reduce IPV for use among young heterosexual couples in South Africa
采用循证干预措施减少南非年轻异性夫妇使用 IPV
- 批准号:
MR/X004090/1 - 财政年份:2023
- 资助金额:
$ 0.87万 - 项目类别:
Research Grant
A dyadic exercise approach to prevent declines in physical and mental health in couples during radiation treatment for cancer: a hybrid type I efficacy-implementation trial
预防癌症放射治疗期间夫妇身心健康下降的二元运动方法:I 型混合疗效实施试验
- 批准号:
10751976 - 财政年份:2023
- 资助金额:
$ 0.87万 - 项目类别:
Information about the adoption and foster care for the couples of infertility treatment
不孕不育治疗夫妇收养、寄养信息
- 批准号:
23K16356 - 财政年份:2023
- 资助金额:
$ 0.87万 - 项目类别:
Grant-in-Aid for Early-Career Scientists