GENOME-WIDE DISTRIBUTION OF ANCESTRY IN MEXICAN AMERICANS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 移民到新大陆的人至少来自三大洲。 这些土著和移民人口相互交配，随后形成了新的混合人口，如非洲裔和拉丁美洲裔美国人。 这些前所未有的事件将数万年来在不同大陆上独立进化的基因组汇集在一起，并为土著和移民人口及其后代提出了新的环境挑战。 这些环境为自然选择的发生提供了新的机会，这可以反映在特定选择位点的全基因组祖先分布的偏离上。 在这里，我们提出了一个分析研究欧洲，美洲原住民和非洲血统的基础上284微卫星标记的研究墨西哥裔美国人的家庭血压计划。 我们确定了非洲血统显着减少的两个基因组区域（在2p25.1，p < 10-8和9p24.1，p<2x 10 -5）和欧洲血统显着增加的一个区域（在1 p33，p< 2 ² 10-5）。我们发现这些区域与血压无关。 这些地点可能含有在墨西哥人祖先混合中受到自然选择的基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Migrations to the new world brought together individuals from at least three continents. These indigenous and migrant populations inter-mated and subsequently formed new admixed populations, such as African and Latino Americans. These unprecedented events brought together genomes that had evolved independently on different continents for tens of thousands of years and presented new environmental challenges for the indigenous and migrant populations, as well as their offspring. These circumstances provided novel opportunities for natural selection to occur that could be reflected in deviations from the genome-wide ancestry distribution at specific selected loci. Here we present an analysis examining European, Native American and African ancestry based on 284 microsatellite markers in a study of Mexican Americans from the Family Blood Pressure Program. We identified two genomic regions where there was a significant decrement in African ancestry (at 2p25.1, p < 10-8 and 9p24.1, p< 2x10-5) and one region with a significant increase in European ancestry (at 1p33, p< 2 ¿ 10-5). We show that these regions are not related to blood pressure. These locations may harbor genes that have been subjected to natural selection in the ancestral mixing of Mexicans.