GENOME-WIDE DISTRIBUTION OF ANCESTRY IN MEXICAN AMERICANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 迁徙到新大陆的人们聚集了至少三大洲的人。这些土著人口和移民人口相互交配，随后形成了新的混合人口，如非洲裔和拉丁裔美国人。这些史无前例的事件汇集了几万年来在不同大陆独立进化的基因组，给土著和移徙人口及其后代带来了新的环境挑战。这些情况为自然选择的发生提供了新的机会，这可以从特定选定基因座对全基因组祖先分布的偏离中反映出来。在这里，我们提出了一项基于284个微卫星标记的分析，该分析基于家庭血压计划对墨西哥裔美国人的研究，调查了欧洲人、美洲原住民和非洲人的祖先。我们发现了两个非洲血统显著减少的基因组区域(2p25.1，p&lt；10-8和9p24.1，p&lt；2x10-5)和一个欧洲血统显著增加的区域(1p33，p&lt；2？10-5)。我们发现这些区域与血压无关。这些位置可能含有在墨西哥人祖先混合中经历了自然选择的基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Migrations to the new world brought together individuals from at least three continents. These indigenous and migrant populations inter-mated and subsequently formed new admixed populations, such as African and Latino Americans. These unprecedented events brought together genomes that had evolved independently on different continents for tens of thousands of years and presented new environmental challenges for the indigenous and migrant populations, as well as their offspring. These circumstances provided novel opportunities for natural selection to occur that could be reflected in deviations from the genome-wide ancestry distribution at specific selected loci. Here we present an analysis examining European, Native American and African ancestry based on 284 microsatellite markers in a study of Mexican Americans from the Family Blood Pressure Program. We identified two genomic regions where there was a significant decrement in African ancestry (at 2p25.1, p < 10-8 and 9p24.1, p< 2x10-5) and one region with a significant increase in European ancestry (at 1p33, p< 2 ¿ 10-5). We show that these regions are not related to blood pressure. These locations may harbor genes that have been subjected to natural selection in the ancestral mixing of Mexicans.