ENTH AND BAR DOMAINS

ENTH 和 Bar 域

• 批准号: 7956512
• 负责人: WONHWA CHO
• 金额: $ 3.55万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956512
• 关键词: Clathrin; Computer Retrieval of Information on Scientific Projects Database; Endocytosis; Fluorescence; Funding; Grant; Institution; Laboratories; Lipid Binding; Measures; Mediating; Membrane; Research; Research Personnel; Resources; Source; Surface; Time; United States National Institutes of Health; Vesicle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ENTH and BAR domains are modular lipid-binding domains that have been implicated in membrane deformation during clathrin-mediated endocytosis. Results from our laboratory as well as from others have indicated that self-association of these domains on the membrane surface is essential for their membrane-deforming activities. To elucidate the mechanisms by which these domains induce membrane deformation, we propose to measure the degree of their self-association on giant unilamellar vesicles in a time-dependent manner by N and B analysis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 ENTH和条状结构域是模块化脂质结合结构域，在网格蛋白介导的内吞作用期间与膜变形有关。我们实验室以及其他实验室的结果表明，这些域在膜表面上的自我关联对于它们的膜形成活动至关重要。为了阐明这些结构域诱导膜变形的机制，我们建议通过N和B分析以时间依赖的方式来测量其对巨型Unilamelar囊泡的自我关联程度。