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ENTH AND BAR DOMAINS

ENTH AND BAR DOMAINS
ENTH 和 Bar 域
批准号:
7956512
负责人:
WONHWA CHO
金额:
$3.55万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-08-01 至 2010-07-31

项目摘要

项目成果

WONHWA CHO的其他基金

相关文献

中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ENTH and BAR domains are modular lipid-binding domains that have been implicated in membrane deformation during clathrin-mediated endocytosis. Results from our laboratory as well as from others have indicated that self-association of these domains on the membrane surface is essential for their membrane-deforming activities. To elucidate the mechanisms by which these domains induce membrane deformation, we propose to measure the degree of their self-association on giant unilamellar vesicles in a time-dependent manner by N and B analysis.
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Lipid regulation of cellular signaling and protein-protein interactions
Lipid regulation of cellular signaling and protein-protein interactions
Regulatory Roles of Cellular Cholesterol
Membrane Targeting by Phosphoinositide-Binding Proteins