SODIUM MRI OF THE BRAIN OF PATIENTS WITH ALZHEIMER?S DISEASE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 人们对开发新的非侵入性技术用于诊断 阿尔茨海默病（AD）及其进展。因为磁共振成像（MRI）是 非侵入性和常规进行设置的神经系统疾病，实施新的 基于MRI的技术用于AD的诊断和预后特别有利。以来 钠（23 Na）MRI已被证明对细胞死亡和活力敏感，我们测试了是否 早期的变化可以在阿尔茨海默病中看到，这种疾病的神经细胞死亡已经很好地 在这些研究中，我们比较了钠MRI与常规MRI的测量结果， 年龄匹配的AD患者和非AD患者的大脑扫描。我们还测量钠 对已故AD患者的脑组织进行了测量，并与组织学检查结果进行了比较。 疾病的措施。到目前为止，我们已经证明了钠MRI的差异， 与轻度AD的存在相关性优于常规标志物。正在进行的研究希望 为了在更大的患者群体中重现这种效果，并进一步了解潜在的 这一现象的机制。希望通过进一步的研究，钠MRI可能是一种 AD定量诊断和疾病追踪的有用工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is significant interest in the development of novel non-invasive techniques for the diagnosis of Alzheimer disease (AD) and tracking its progression. Because magnetic resonance imaging (MRI) is non-invasive and routinely performed in the setting of neurological disease, implementation of new MRI-based techniques for the diagnosis and prognosis of AD are especially advantageous. Since sodium (23Na) MRI has been shown to be sensitive to cell death and viability, we tested whether early changes would be seen in Alzheimer disease, a disease where neural cell death has been well established.For these studies we compare measurements made with sodium MRI with conventional brain scanning in age-matched participants with and without AD. We also measure sodium measures on brains willed to us from deceased AD patients and compare that with histologic measures of disease. So far we have demonstrated differences in sodium MRI that seem to correlate better with the presence of mild AD than conventional markers. Ongoing studies hope to reproduce this effect in larger groups of patients and further understand the underlying mechanism of this phenomenon. It is hoped that with further study sodium MRI may be a useful tool for the quantitative diagnosis and disease tracking of AD.