SODIUM MRI OF THE BRAIN OF PATIENTS WITH ALZHEIMER?S DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人们对开发新的非侵入性诊断技术有很大的兴趣 阿尔茨海默病(AD)和跟踪其进展。因为磁共振成像(MRI)是 在神经系统疾病的环境中进行非侵入性和常规操作，实施新的 基于MRI的技术对AD的诊断和预后尤为有利。自.以来 钠(23Na)核磁共振已被证明对细胞死亡和活性敏感，我们测试了 阿尔茨海默病可以看到早期的变化，这种疾病的神经细胞死亡一直很好 在这些研究中，我们比较了钠核磁共振和常规核磁共振的测量结果。 年龄匹配的阿尔茨海默病患者和非AD患者的脑扫描。我们还测量钠 已故AD患者脑组织标本的测量及其与组织学的比较 疾病的衡量标准。到目前为止，我们已经证明了钠核磁共振的不同之处 与常规标记物相比，轻度阿尔茨海默病的相关性更好。正在进行的研究希望 为了在更大的患者群体中重现这种效应，并进一步了解潜在的 这一现象的发生机制。希望随着进一步的研究，钠核磁共振可能成为一种 为AD的定量诊断和疾病追踪提供有用的工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is significant interest in the development of novel non-invasive techniques for the diagnosis of Alzheimer disease (AD) and tracking its progression. Because magnetic resonance imaging (MRI) is non-invasive and routinely performed in the setting of neurological disease, implementation of new MRI-based techniques for the diagnosis and prognosis of AD are especially advantageous. Since sodium (23Na) MRI has been shown to be sensitive to cell death and viability, we tested whether early changes would be seen in Alzheimer disease, a disease where neural cell death has been well established.For these studies we compare measurements made with sodium MRI with conventional brain scanning in age-matched participants with and without AD. We also measure sodium measures on brains willed to us from deceased AD patients and compare that with histologic measures of disease. So far we have demonstrated differences in sodium MRI that seem to correlate better with the presence of mild AD than conventional markers. Ongoing studies hope to reproduce this effect in larger groups of patients and further understand the underlying mechanism of this phenomenon. It is hoped that with further study sodium MRI may be a useful tool for the quantitative diagnosis and disease tracking of AD.