SODIUM MRI OF THE BRAIN OF PATIENTS WITH ALZHEIMER?S DISEASE

阿尔茨海默病患者脑部的钠 MRI

• 批准号: 7955313
• 负责人: Eric Albert Mellon
• 金额: $ 2.78万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955313
• 关键词: Age; Alzheimer' s Disease; Brain; Brain scan; Cell Death; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnosis; Disease; Funding; Grant; Histologic; Institution; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Neurons; Participant; Patients; Research; Research Personnel; Resources; Sodium; Source; Techniques; Testing; United States National Institutes of Health; base; disease diagnosis; interest; nervous system disorder; novel; optical imaging; outcome forecast; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is significant interest in the development of novel non-invasive techniques for the diagnosis of Alzheimer disease (AD) and tracking its progression. Because magnetic resonance imaging (MRI) is non-invasive and routinely performed in the setting of neurological disease, implementation of new MRI-based techniques for the diagnosis and prognosis of AD are especially advantageous. Since sodium (23Na) MRI has been shown to be sensitive to cell death and viability, we tested whether early changes would be seen in Alzheimer disease, a disease where neural cell death has been well established.For these studies we compare measurements made with sodium MRI with conventional brain scanning in age-matched participants with and without AD. We also measure sodium measures on brains willed to us from deceased AD patients and compare that with histologic measures of disease. So far we have demonstrated differences in sodium MRI that seem to correlate better with the presence of mild AD than conventional markers. Ongoing studies hope to reproduce this effect in larger groups of patients and further understand the underlying mechanism of this phenomenon. It is hoped that with further study sodium MRI may be a useful tool for the quantitative diagnosis and disease tracking of AD.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 人们对开发用于诊断的新型非侵入性技术非常感兴趣 阿尔茨海默病（AD）并追踪其进展。因为磁共振成像 (MRI) 在神经系统疾病的情况下进行非侵入性和常规执行，实施新的 基于 MRI 的技术对于 AD 的诊断和预后尤其有利。自从 钠 (23Na) MRI 已被证明对细胞死亡和活力敏感，我们测试了是否 早期的变化可以在阿尔茨海默病中看到，这种疾病的神经细胞死亡已得到很好的控制。 对于这些研究，我们将钠 MRI 的测量结果与传统的测量结果进行比较 对年龄匹配的患有或不患有 AD 的参与者进行脑部扫描。我们还测量钠 对已故 AD 患者的大脑进行测量，并将其与组织学进行比较 疾病的措施。到目前为止，我们已经证明了钠 MRI 的差异，这些差异似乎 与传统标记物相比，该标记物与轻度 AD 的存在具有更好的相关性。正在进行的研究希望 在更大的患者群体中重现这种效应并进一步了解潜在的原因 这种现象的发生机制。希望通过进一步的研究，钠 MRI 可能成为一种新的方法。 AD 定量诊断和疾病追踪的有用工具。