IDENTIFICATION OF PAX7 INTERACTING PROTEINS
IDENTIFICATION OF PAX7 INTERACTING PROTEINS
批准号:
7957715
负责人:
Bradley B Olwin
金额:
$0.33万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-09-01 至 2010-08-31
关键词:
AffectBiologyCell physiologyCollaborationsCommitComputer Retrieval of Information on Scientific Projects DatabaseDNA BindingFundingFungal GenomeGoalsGrantInstitutionMuscleMuscle FibersMyogeninPAX7 genePaired box protein Pax-7ProliferatingProteinsResearchResearch PersonnelResourcesSkeletal MuscleSourceUnited States National Institutes of Healthmuscle regenerationsatellite cellself-renewaltranscription factor
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
PAX7是骨骼肌再生过程中卫星细胞功能所必需的一种肌肉转录因子。Pax7蛋白的水平受转录后调控,影响卫星细胞自我更新或致力于肌源性分化的决定。这一决定的一部分似乎是由卫星细胞中MyoD和肌肉生成素的水平决定的。高Pax7水平导致MyoD降解,高MyoD水平导致Pax7降解。我们假设这些蛋白质竞争DNA结合和稳定所需的共同因子。这项合作的目标是确定增殖的骨骼肌细胞中直接或间接与Pax7相互作用的蛋白质。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Pax7 is a muscle transcription factor necessary for satellite cell function in skeletal muscle regeneration. The levels of Pax7 protein are regulated post-transcriptionally and affect the decision of a satellite cell to self-renew or commit to myogenic differentiation. Part of this decision appears to be determined by the levels of MyoD and myogenin in satellite cells. High Pax7 levels induce MyoD degradation and high MyoD levels cause Pax7 degradation. We hypothesize that these proteins compete for a common factor that is required for DNA binding and stabilization. The goal of this collaboration is to identify proteins in proliferating skeletal muscle cells that interact directly or indirectly with Pax7.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Replicative Potential of Muscle Stem Cells
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批准号:10685322
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项目类别:
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资助金额:$50.73万
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财政年份:2017
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负责人:Bradley B Olwin
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依托单位:
Replicative Potential of Muscle Stem Cells
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批准号:10226080
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项目类别:
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资助金额:$32.86万
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财政年份:2017
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Replicative Potential of Muscle Stem Cells
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批准号:10530885
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项目类别:
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资助金额:$52.74万
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财政年份:2017
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负责人:Bradley B Olwin
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依托单位:
Replicative Potential of Muscle Stem Cells
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批准号:9403495
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项目类别:
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资助金额:$33.88万
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财政年份:2017
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负责人:Bradley B Olwin
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依托单位:
Age-Dependent Regulation of Muscle Stem Cell Homeostasis
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批准号:8688866
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项目类别:
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资助金额:$33.84万
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财政年份:2011
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负责人:Bradley B Olwin
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依托单位:
Age-Dependent Regulation of Muscle Stem Cell Homeostasis
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批准号:8509564
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项目类别:
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资助金额:$31.99万
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财政年份:2011
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负责人:Bradley B Olwin
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依托单位:
Age-Dependent Regulation of Muscle Stem Cell Homeostasis
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批准号:8163849
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项目类别:
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资助金额:$33.87万
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财政年份:2011
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负责人:Bradley B Olwin
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依托单位:
Age-Dependent Regulation of Muscle Stem Cell Homeostasis
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批准号:8317555
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项目类别:
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资助金额:$33.86万
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财政年份:2011
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负责人:Bradley B Olwin
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依托单位:
Age-Dependent Regulation of Muscle Stem Cell Homeostasis
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批准号:8897214
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项目类别:
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资助金额:$32.81万
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财政年份:2011
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负责人:Bradley B Olwin
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依托单位:
Role of Syndecans in Satellite Cell Function
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批准号:7924400
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项目类别:
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资助金额:$15.73万
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财政年份:2009
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负责人:Bradley B Olwin
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依托单位:
IDENTIFICATION OF PAX7 INTERACTING PROTEINS
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批准号:7723614
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项目类别:
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资助金额:$0.81万
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财政年份:2008
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负责人:Bradley B Olwin
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依托单位:
Age-related Changes in a Myogenic Niche
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批准号:7463825
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项目类别:
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资助金额:$26.16万
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财政年份:2006
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负责人:Bradley B Olwin
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依托单位:
Age-related Changes in a Myogenic Niche
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批准号:7898576
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项目类别:
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资助金额:$25.9万
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财政年份:2006
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负责人:Bradley B Olwin
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依托单位:
Age-related Changes in a Myogenic Niche
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批准号:7148629
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项目类别:
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资助金额:$27.13万
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财政年份:2006
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负责人:Bradley B Olwin
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依托单位:
Age-related Changes in a Myogenic Niche
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批准号:7265123
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项目类别:
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资助金额:$26.69万
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财政年份:2006
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负责人:Bradley B Olwin
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依托单位:
Age-related Changes in a Myogenic Niche
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批准号:7645025
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项目类别:
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资助金额:$26.16万
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财政年份:2006
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负责人:Bradley B Olwin
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依托单位:
2006 Fibroblast Growth Factors in Development and Diseases
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批准号:7214225
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项目类别:
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资助金额:$0.3万
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财政年份:2005
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负责人:Bradley B Olwin
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依托单位:
Mechanisms Regulating Muscle Stem Cell Homeostasis
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批准号:9315106
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项目类别:
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资助金额:$33.57万
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财政年份:2005
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负责人:Bradley B Olwin
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依托单位:
Role of Syndecans in Satellite Cell Function
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批准号:7046092
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项目类别:
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资助金额:$30.92万
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财政年份:2005
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负责人:Bradley B Olwin
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依托单位:
Mechanisms Regulating Muscle Stem Cell Homeostasis
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批准号:10669506
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项目类别:
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资助金额:$52.12万
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财政年份:2005
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负责人:Bradley B Olwin
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依托单位:
国内基金
海外基金
Journal of Integrative Plant Biology
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批准号:31024801
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项目类别:专项基金项目
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资助金额:24.0万元
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批准年份:2010
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负责人:贺萍
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依托单位: