STRUCTURAL DETERMINATION OF LACTOSE PERMEASE IN DIFFERENT CONFORMATIONS
不同构象的乳糖渗透酶的结构测定
基本信息
- 批准号:7954411
- 负责人:
- 金额:$ 0.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-03-01 至 2010-02-28
- 项目状态:已结题
- 来源:
- 关键词:ComplexComputer Retrieval of Information on Scientific Projects DatabaseEscherichia coliFundingGoalsGrantHomologous GeneInstitutionIon CotransportLactoseMembrane Transport ProteinsMolecular ConformationResearchResearch PersonnelResolutionResourcesSourceStructureUnited States National Institutes of Healthimprovedlactose permeasemutantresearch studystructural biologysynchrotron radiation
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The goal of the experiment is to determine the mechanism of lactose/H+ symport by the lactose permease of E. coli (LacY), a paradigm for the Major Facilitator Superfamily (MFS) of membrane transport proteins. We plan to solve structures of different conformations of LacY and improve the resolution and quality of currently available crystal structure. For this we obtained crystals of different LacY substrates complexes, mutants, or homologues. We need to screen several hundred crystals and then perform MAD experiments on selected crystals. This requires regular access to synchrotron radiation
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jun-Yong Choe其他文献
Jun-Yong Choe的其他文献
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{{ truncateString('Jun-Yong Choe', 18)}}的其他基金
Ligand specificity in human glucose transporters GLUT1-5 and GLUT9
人葡萄糖转运蛋白 GLUT1-5 和 GLUT9 的配体特异性
- 批准号:
9290407 - 财政年份:2017
- 资助金额:
$ 0.02万 - 项目类别:
STRUCTURAL AND FUNCTIONAL ANALYSIS OF GLUCOSE TRANSPORTERS
葡萄糖转运蛋白的结构和功能分析
- 批准号:
8194680 - 财政年份:2011
- 资助金额:
$ 0.02万 - 项目类别:
STRUCTURAL AND FUNCTIONAL ANALYSIS OF GLUCOSE TRANSPORTERS
葡萄糖转运蛋白的结构和功能分析
- 批准号:
8289445 - 财政年份:2011
- 资助金额:
$ 0.02万 - 项目类别:
STRUCTURAL AND FUNCTIONAL ANALYSIS OF GLUCOSE TRANSPORTERS
葡萄糖转运蛋白的结构和功能分析
- 批准号:
8496768 - 财政年份:2011
- 资助金额:
$ 0.02万 - 项目类别:
STRUCTURAL AND FUNCTIONAL ANALYSIS OF GLUCOSE TRANSPORTERS
葡萄糖转运蛋白的结构和功能分析
- 批准号:
8663247 - 财政年份:2011
- 资助金额:
$ 0.02万 - 项目类别:
STRUCTURE DETERMINATION OF TRANSMEMBRANE CARBOHYDRATE TRANSPORTER PROTEINS
跨膜碳水化合物转运蛋白的结构测定
- 批准号:
8361721 - 财政年份:2011
- 资助金额:
$ 0.02万 - 项目类别:
STRUCTURAL AND FUNCTIONAL ANALYSIS OF GLUCOSE TRANSPORTERS
葡萄糖转运蛋白的结构和功能分析
- 批准号:
8852599 - 财政年份:2011
- 资助金额:
$ 0.02万 - 项目类别:
STRUCTURAL DETERMINATION OF LACTOSE PERMEASE IN DIFFERENT CONFORMATIONS
不同构象的乳糖渗透酶的结构测定
- 批准号:
8170084 - 财政年份:2010
- 资助金额:
$ 0.02万 - 项目类别:
STRUCTURAL DETERMINATION OF LACTOSE PERMEASE IN DIFFERENT CONFORMATIONS
不同构象的乳糖渗透酶的结构测定
- 批准号:
7722102 - 财政年份:2008
- 资助金额:
$ 0.02万 - 项目类别: