CRYSTAL STRUCTURE OF DCR3-TL1A COMPLEX

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 诱骗受体3(DcR3)是一种分泌型免疫抑制蛋白，属于肿瘤坏死因子受体超家族。DcR3‘S的作用机制是复杂的，因为它能够中和三种不同的肿瘤坏死因子配体：FasL、LIGHT和TL1a。这些配体中的每一个都与不同的功能受体结合，随后将免疫反应引导到不同的目的地。了解DcR3及其配体之间的相互作用可能会为包括慢性疾病和类风湿性关节炎在内的各种人类疾病提供治疗机会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Decoy Receptor 3 (DcR3) is a secreted immunosuppressive protein that belongs to the Tumor Necrosis Factor (TNF) receptor superfamily. The dissection of DcR3's functional mechanism is complicated by its capacity to neutralize three different TNF ligands: FasL, LIGHT, and TL1A. Each of these ligands binds distinct functional receptors and subsequently directs immune responses to different destinations. The understanding of the interactions between DcR3 and its ligands may provide therapeutic opportunities to a variety of human diseases, including Chron's disease and rheumatoid arthritis.