CRYSTAL STRUCTURE OF DCR3-TL1A COMPLEX
CRYSTAL STRUCTURE OF DCR3-TL1A COMPLEX
批准号:
7955210
负责人:
STEVEN G ALMO
金额:
$0.53万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-04-01 至 2010-03-31
关键词:
ComplexComputer Retrieval of Information on Scientific Projects DatabaseDestinationsDiseaseDissectionFundingGrantImmune responseImmunosuppressive AgentsInstitutionLigand BindingLigandsProteinsResearchResearch PersonnelResourcesRheumatoid ArthritisSourceStructureTherapeuticTumor Necrosis Factor ReceptorTumor Necrosis Factor-alphaTumor Necrosis FactorsUnited States National Institutes of Healthdecoy receptor 3human diseasereceptorstructural biology
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Decoy Receptor 3 (DcR3) is a secreted immunosuppressive protein that belongs to the Tumor Necrosis Factor (TNF) receptor superfamily. The dissection of DcR3's functional mechanism is complicated by its capacity to neutralize three different TNF ligands: FasL, LIGHT, and TL1A. Each of these ligands binds distinct functional receptors and subsequently directs immune responses to different destinations. The understanding of the interactions between DcR3 and its ligands may provide therapeutic opportunities to a variety of human diseases, including Chron's disease and rheumatoid arthritis.
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CRYSTAL STRUCTURE OF DCR3-TL1A COMPLEX
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批准号:8169276
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项目类别:
-
资助金额:$0.18万
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财政年份:2010
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负责人:STEVEN G ALMO
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依托单位:
METABOLIC SPECIFICITY OF METHYLTHIOCOFORMYCIN FOR MALARIAL ADENOSINE DEAMINASE
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批准号:8169275
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项目类别:
-
资助金额:$0.17万
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财政年份:2010
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负责人:STEVEN G ALMO
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依托单位:
MALARIAL ADENOSINE DEAMINASES
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批准号:7955209
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项目类别:
-
资助金额:$0.54万
-
财政年份:2009
-
负责人:STEVEN G ALMO
-
依托单位: