ROLE OF GALANIN-EXPRESSING LEPTIN RECEPTOR NEURONS IN LEPTIN ACTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项题为“在瘦素作用中甘丙肽/瘦素受体神经元在背内侧下丘脑和弓状核内的作用”的提议旨在研究在背内侧下丘脑（DMH）和弓状核（ARC）内发现的甘丙肽和瘦素受体表达神经元（gal/LepRb神经元）的新群体。已发现激素瘦素在人类和啮齿动物的能量稳态的中枢调节中是至关重要的。在这里，瘦素作用于其受体（LepRb）， 然而，在摄食回路和能量消耗方面，个体中枢瘦素受体表达位点对于瘦素作用的重要性在很大程度上是未知的。新鉴定的gal/LepRb神经元群体与ARC中其他已知的LepRb群体不同，并且拟议研究的总体目标是了解它们在调节食物消耗和能量稳态中的综合作用

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal entitled "Role of galanin/leptin receptor neurons within the dorsomedial hypothalamus and arcuate nucleus in leptin action" aims to investigate a novel population of galanin and leptin receptor expressing neurons (gal/LepRb neurons) found within the dorsomedial hypothalamus (DMH) and the arcuate nucleus (ARC). The hormone leptin has been found to be crucial for humans and rodents in the central regulation of energy homeostasis. Here, leptin acts on its receptor (LepRb) to regulate feeding circuits and energy expenditure, however, the importance of individual central leptin receptor expressing sites for leptin action is largely unknown. The newly identified population of gal/LepRb neurons is distinct from other known LepRb populations in the ARC and the overall objective of the proposed studies is to understand their integrated role in regulating food consumption and energy homeostasis